Fgfr2 Knockout (Fgfr2tm1Cxd) Mouse Model for Developmental Biology Studies


FGFR2 knockout is an embryonic lethal mutation and blocks limb bud initiation.

Fibroblast Growth Factor Receptor 2 (FGFR2) is a high affinity receptor for several members of the FGF family. The FGFR2 gene was inactivated by deleting the entire immunoglobulin-like domain of the receptor which is critical for FGF binding and FGFR2 activity. Embryos that lack this domain die at E10-11.5 owing to a failure in chorioallantoic fusion or placental formation. The deletion also blocks limb bud initiation, establishing FGFR2 as the major receptor that mediates FGF signals during limb induction.

Potential Commercial Applications: Competitive Advantages:
  • Mouse model to study developmental biology.
 


Development Stage:
Pre-clinical

Inventors:

Chuxia Deng (NIDDK)  ➽ more inventions...


Intellectual Property:
Research Tool — Patent protection is not being pursued for this technology.

Publications:
Xu X, et al. PMID 9435295

Licensing Contact:
Betty Tong, Ph.D.
Email: tongb@niddk.nih.gov
Phone: 301-451-7836

OTT Reference No: E-124-2012-0
Updated: May 14, 2018