mGluR5 Tumor Mouse Model

Glutamate receptor mGluR5 has been reported to function in the brain. There were no prior reports of it being involved in melanoma. The NIH investigators have discovered that when over expressed in transgenic animals, mGluR5 induces melanoma. The establishment of an mGluR5 tumor mouse model will provide a unique opportunity to help elucidate the mechanisms underlying tumor formation, and allow the study of aggressive melanoma in animals and a screen of potential therapeutics. Such an mGluR5 tumor mouse model is established at the National Institutes of Health and is available for licensing.

Potential Commercial Applications: Competitive Advantages:
  • Drug screening for melanoma therapeutics
  • Research Tool
 Tumor mouse model only available from the NIH lab.

Development Stage:
  • Prototype
  • Pre-clinical
  • In vivo data available (animal)


Katherine Roche (NINDS)  ➽ more inventions...

Kyu Yeong Choi (NINDS)  ➽ more inventions...

Intellectual Property:
Research Tool — Patent protection is not being pursued for this technology

Choi KY, et al. PMID 21896768

Licensing Contact:
Smita Sharma, Ph.D., J.D.
Phone: 301-435-7761

OTT Reference No: E-123-2010-0
Updated: Sep 29, 2011