A Current Amplifier for Local Coil Pre-amplification of NMR/MRI Signals

The magnetic resonance imaging (MRI) systems are used for a variety of imaging application. The present invention discloses an improving MRI device and method by amplifying signals received by resonant NMR coils of MRI systems. It utilizes positive feedback from low-noise Field-Effect Transistor to amplify the signal current that can be coupled out to receiving loops positioned externally without loss in sensitivity. Therefore, the NMR coil can be flexibly positioned near internal tissues and used to develop high-resolution images in highly invasive situations. The disclosed device can be developed in kit form as integrated modules that are designed to be added to tuned NMR receiver coils and tailored to deliver specific gains at NMR frequencies.

Potential Commercial Applications: Competitive Advantages:
  • Medical and scientific research
  • Device for diagnostic
  • Sensitivity
  • Easy to be integrated into the existed device

Development Stage:
  • In vitro data available
  • In vivo data available (animal)


Joseph Murphy-Boesch (NINDS)  ➽ more inventions...

Stephen Dodd (NINDS)  ➽ more inventions...

Alan Koretsky (NINDS)  ➽ more inventions...

Chunqi Qian (NINDS)  ➽ more inventions...

Intellectual Property:
U.S. Pat: 10,393,831 issued 2019-08-27
US Application No. 61/989,795
PCT Application No. PCT/US2015/029674

Qian C, et al. PMID 23392428
Qian C, et al. PMID 22246567
Mueller OM, et al. US Patent 5,545,999 (1996)
Ratzel D. US Patent 7,123,090 (2006)

Collaboration Opportunity:

The National Institute of Neurological Disorders and Stroke, Laboratory for Functional and Molecular Imaging, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize a surgically implantable NMR detector, battery powered, for imaging of the pituitary. For collaboration opportunities, please contact Joseph Murphy-Boesch at murphyboeschj@mail.nih.gov.

Licensing Contact:
Susan Ano, Ph.D.
Email: susan.ano@nih.gov
Phone: 301-435-5515

OTT Reference No: E-122-2014-0
Updated: May 18, 2018