Mouse Monoclonal Antibodies to MAD1, a Human Spindle Assembly Checkpoint Protein for Maintaining Chromosomal Segregation

Scientists at the National Institutes of Health have developed mouse monoclonal antibodies against the human spindle assembly checkpoint protein, MAD1. The spindle assembly checkpoint in mitotic cell division regulates the fidelity of chromosome segregation during cell division. MAD1 is an important component of this checkpoint control, which if compromised, can lead to the initiation of cancer cell growth. These monoclonal antibodies are the first available antibodies against MAD1 and can be used in laboratory research and diagnostics.

Potential Commercial Applications: Competitive Advantages:
  • Research tool in various laboratory procedures to identify and detect MAD1
  • Diagnostic tool for aneuploidy, the condition of having an abnormal number of chromosomes, which results in birth and dev delopmental defects, such as Down syndrome


Kuan-teh Jeang (Estate) (NIAID)  ➽ more inventions...

Intellectual Property:
Research Tool -- Patent protection is not being pursued for this technology

Haller K, et al. PMID 16288203

Collaboration Opportunity:

The NIAID NIAID Technology Transfer & Intellectual Property Office is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize reagents for studying cell cycle checkpoint factors.

Licensing Contact:
Carol Salata, Ph.D.
Phone: 240-627-3727

OTT Reference No: E-119-2003-0
Updated: Jan 19, 2016