A Novel X-ray Grating to Enhance Phase Contrast Imaging

The present invention relates to improving x-ray phase contrast imaging. The invention discloses a novel grating interferometer for phase contrast imaging with hard x-rays that overcomes limitations in the level of sensitivity by utilizing the advantages of far-field interferometers. The novel design and fabrication process can easily acquire absolute and differential phase images of lightly absorbing samples.

Potential Commercial Applications: Competitive Advantages:
  • Clinical diagnostics
  • Research tools
  • More sensitivity
  • Easier to fabricate images

Development Stage:
  • In vitro data available
  • In vivo data available (animal)


Han Wen (NHLBI)  ➽ more inventions...

Intellectual Property:
US Pat: - issued -
PCT Application No. PCT/US2014/055225 filed on 2014-09-11

Wen H. Boosting phase contrast with two-arm interferometers using sub-micron period gratings. Presentation - Session 2, The Royal Society, London scientific discussion meeting: Taking x-ray phase contrast imaging into mainstream applications, February 11, 2013, London, UK. [Abstract]
Momose A, Fukuda J. [PMID 7609717]
Clauser JF. [US Patent No. 5,812,629]

Collaboration Opportunity:

The National Heart, Lung, and Blood Institute is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize the technology. For collaboration opportunities, please contact Dr. Denise Crooks at crooksd@mail.nih.gov.

Licensing Contact:
Michael Shmilovich, J.D.
Email: shmilovm@mail.nih.gov
Phone: 301-435-5019

OTT Reference No: E-114-2013-0
Updated: May 18, 2018