A Novel Demodulation System in X-ray Imaging

In various x-ray imaging methods, including scattering correction and phase contrast imaging, intensity modulation in space is introduced into the projection images by the use of masks, gratings, or apertures. The present invention relates to a process to demodulate the modulation. The current demodulation processes are either to remove the modulation pattern through digital processing or to move the modulation pattern on the detector in a series of images that requires mechanical movements of a component and tends to lose some information of the imaged object. The demodulation of the present invention can be realized with a relative movement between the projected image of the sample and the modulation pattern without having to move the modulation pattern. The demodulated images are free of the modulation pattern and have better clarity.

Potential Commercial Applications: Competitive Advantages:
  • Clinical diagnostic
  • Research tools
  • Security inspections
  • Better clarity for images
  • Simplify the demodulation method

Development Stage:
  • In vitro data available
  • In vivo data available (animal)


Han Wen (NHLBI)  ➽ more inventions...

Houxun Miao (NHLBI)  ➽ more inventions...

Intellectual Property:
US Pat: 9,939,392 issued 2018-04-10
US Application No. 61/877,219 filed on 2013-09-12
PCT Application No. PCT/US2014/055224 filed on 2014-09-11

David C, et al. US Patent No. 7,889,838
Schusser S, Vogtmeier G. PCT Application No. PCT/IB2010/055562

Collaboration Opportunity:

The National Heart, Lung, and Blood Institute is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize the technology. For collaboration opportunities, please contact Dr. Denise Crooks at crooksd@mail.nih.gov.

Licensing Contact:
Michael Shmilovich, J.D.
Email: shmilovm@mail.nih.gov
Phone: 301-435-5019

OTT Reference No: E-113-2013-0
Updated: May 18, 2018