EGFRvIII Antibodies for the Treatment of Human Cancer
Epidermal growth factor receptor variant III (EGFRvIII) is a variant of EGFR that is an excellent target for immunotherapy because of its expression in cancer cells and not in normal cells.
Inventors from the National Cancer Institute (NCI) have isolated seven mouse monoclonal antibodies that bind to the human EGFRvIII but not wildtype EGFR. These EGFRvIII antibodies can be used as either independent agents or targeting domains in recombinant immunotoxins (RITs), antibody-drug conjugates (ADCs), bispecific antibodies, and chimeric antigen receptors (CARs). Significantly, RITs using one of the antibodies (40H3) have shown potent killing in breast cancer cells and in epidermoid cancer cells, strongly supporting that the antibodies may be further developed as therapeutics. The 40H3 antibody is also able to bind to EGFR when overexpressed as seen in various cancers, and thus has broad therapeutic potential.
The NCI seeks research co-development partners or licensees for monoclonal antibodies that specifically target cancer-expressed EGFR.
Potential Commercial Applications: | Competitive Advantages: |
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Development Stage:
Discovery (Lead Identification)
Inventors:
David FitzGerald (NCI) ➽ more inventions...
Eric Chun Hei Ho (NCI) ➽ more inventions...
Antonella Antignani (NCI) ➽ more inventions...
Robert Sarnovsky (NCI) ➽ more inventions...
Intellectual Property:
Application No. 62/869,956
Collaboration Opportunity:
Licensing and research collaboration
Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515
OTT Reference No: E-103-2019
Updated: Apr 28, 2020