EGFRvIII Antibodies for the Treatment of Human Cancer


Epidermal growth factor receptor variant III (EGFRvIII) is a variant of EGFR that is an excellent target for immunotherapy because of its expression in cancer cells and not in normal cells. 

Inventors from the National Cancer Institute (NCI) have isolated seven mouse monoclonal antibodies that bind to the human EGFRvIII but not wildtype EGFR. These EGFRvIII antibodies can be used as either independent agents or targeting domains in recombinant immunotoxins (RITs), antibody-drug conjugates (ADCs), bispecific antibodies, and chimeric antigen receptors (CARs). Significantly, RITs using one of the antibodies (40H3) have shown potent killing in breast cancer cells and in epidermoid cancer cells, strongly supporting that the antibodies may be further developed as therapeutics. The 40H3 antibody is also able to bind to EGFR when overexpressed as seen in various cancers, and thus has broad therapeutic potential.    

The NCI seeks research co-development partners or licensees for monoclonal antibodies that specifically target cancer-expressed EGFR.



Potential Commercial Applications: Competitive Advantages:
  • Therapeutic applications include the unconjugated antibodies and their use as a targeting moiety in ADCs, RITs, and CARs
  • Diagnostic agent for detection and monitoring levels of EGFRvIII expressing cancers
 
  • The EGFRvIII antibodies with high EGFRvIII binding specificity will result in less non-specific cell killing and lower potential side effects 
  • RITs using the 40H3 antibody are available for immediate testing 
  • 40H3 can also bind EGFR when over-expressed from amplified EGFR, which is specific to various cancers  


Development Stage:
Discovery (Lead Identification)

Inventors:

David FitzGerald (NCI)  ➽ more inventions...

Eric Chun Hei Ho (NCI)  ➽ more inventions...

Antonella Antignani (NCI)  ➽ more inventions...

Robert Sarnovsky (NCI)  ➽ more inventions...


Intellectual Property:
Pat: - issued 2020-07-01
Application No. PCT/US2020/040544 filed on 2020-07-01
Application No. WO 2021/003297

Collaboration Opportunity:

Licensing and research collaboration


Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515

OTT Reference No: E-103-2019
Updated: Mar 29, 2021