Adeno-Associated Virus (AAV)-Based Eucaryotic Vectors


Adeno-associated virus (AAV)-based eucaryotic vectors containing HIV or HSV offer a valuable new method for treating these viral infections. Presently available drugs for inhibiting viral replication have limitations because the viruses have the ability to rapidly mutate and ultimately become resistant to these drugs. These AAV-based eucaryotic vectors have the advantage for inhibiting viral replication because they contain sequences that code for proteins that have been shown to down-regulate specific HIV and HSV replication genes. The AAV-based vectors containing these down-regulating genes can then be used to infect host cells and integrate with their DNA and thus, confer intracellular resistance to infection by these viruses.

Inventors:

K Wong (NIAID)  ➽ more inventions...


Intellectual Property:
U.S. Pat: 5,474,935 issued 1995-12-12
US Application No. 07/752,899
US Application No. PCT/US91/003440

Licensing Contact:
Benjamin Hurley, Ph.D.
Email: benjamin.hurley@nih.gov
Phone: 240-669-5092

OTT Reference No: E-099-1990-0
Updated: Jan 1, 1999