MEN1, The Gene For Multiple Endocrine Neoplasia Type 1


Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized by occurrence of tumors in parathryroids, enteropancreatic endocrine tissues, the anterior pituitary, and occasionally other sites. The present invention provides an isolated DNA sequence encoding a gene which when mutated in the germline is associated with the development of MEN1. This invention also comprises polyclonal and monoclonal antibodies which selectively bind to menin, the protein encoded by MEN1. In addition, the present invention provides methods for immunological detection of menin in biological samples as well as methods for detecting the presence, alteration, or absence of MEN1 DNA or RNA.

Potential areas of application of this invention include sporadic and familial MEN1 diagnostics using immunoassays and nucleic acid hybridizations, and gene therapy.

Inventors:

Settara Chandrasekharappa (NHGRI)  ➽ more inventions...

Lance Liotta (NCI)  ➽ more inventions...

Allen Spiegel (NIDDK)  ➽ more inventions...


Intellectual Property:
U.S. Pat: 7,358,347 issued 2008-04-15
US Application No. 60/040,269
PCT Application No. PCT/US98/04258

Publications:
SC Chandrasekharappa et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 1997 Apr 18;276(5311):404-407. PubMed abs

Licensing Contact:
Eggerton Campbell, Ph.D.
Email: eggerton.campbell@nih.gov
Phone: 301-402-1648

OTT Reference No: E-094-1997-0
Updated: Aug 1, 1997