NAG-1 Transgenic Mouse Model

The nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) encodes a protein that has anti-inflammatory, proapoptotic, and antitumor properties. It plays a pivotal role in antitumorigenesis induced by chemopreventive compounds. Transgenic mice expressing human NAG-1 have been developed by the NIH investigator and collaborator.

The NAG-1 transgenic mice are shown to develop few tumors in response to carcinogenic stimuli than wild type mice. They are also leaner with less fat than their wild type counterparts. As such, these mice can be used to investigate the development of cancers, and they could be of value in studying obesity and the relationship to cancer risk, and inflammation.


Thomas Eling (NIEHS)  ➽ more inventions...

Intellectual Property:
Research Tool — Patent protection is not being pursued for this technology.

Baek SJ, et al. PMID 17101328
Cekanova M, et al. PMID 19401523

Collaboration Opportunity:

The NIEHS is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize this technology. Please contact Elizabeth M. Denholm, NIEHS Office of Technology Transfer,, 919-541-0981, for more information.

Licensing Contact:
Vidita Choudhry, Ph.D.
Phone: 301-594-4095

OTT Reference No: E-093-2011-0
Updated: Apr 17, 2013