Mouse Model of STAT5 for the Drug Screen and the Research of Cancer and Autoimmunity
The invention is a STAT5 mutant mouse that can be used in research related to cancer, autoimmunity and infectious diseases as well as drug screening. The mouse model itself has multiple immunological defects resulting in formation of STAT5 dimers but not tetramers.
It reports that only a minority of IL-2-modulated genes is regulated by STAT5 tetramers. Therefore, selectively targeting tetramer formation might be a relatively specific therapeutic tool wherein one could modulate only part of the actions of a cytokine or growth factor, which allows a new therapeutic approach to modulating immune responses, controlling inflammation, and inhibiting tumor growth.
The STAT5 tetramer deficient mouse is an ideal tool to screen for tetramerization inhibitors that can be used for the treatment of cancer, autoimmunity and inflammation in addition to the basic research applications.
Potential Commercial Applications: | Competitive Advantages: |
|
|
Inventors:
Warren Leonard (NHLBI) ➽ more inventions...
Jian-xin Lin (NHLBI) ➽ more inventions...
Intellectual Property:
Research Tool — Patent protection is not being pursued for this technology.
Publications:
Lin JX, et al. PMID 22520852
Licensing Contact:
Michael Shmilovich, J.D.
Email: shmilovm@mail.nih.gov
Phone: 301-435-5019
OTT Reference No: E-080-2011-0
Updated: Jun 13, 2012