Bag6 Polyclonal Antibodies That Recognize Human Bag6 Protein


Bag6 (BCL2 associated athanogene 6) is a multifunctional chaperone involved in tail anchored protein biogenesis, endoplasmic reticulum-associated protein degradation, and degradation of mislocalized membrane proteins. It is the central component of a stable three chaperone complex that also contains two cofactors-Ubl4A and Trc35. This complex acts in conjunction with the co-chaperone SGTA to channel proteins bearing an exposed hydrophobic segment in the cytosol to avoid protein aggregation. The complex also associates with several ubiquitin ligases including gp78 and RNF126, which link it to protein quality control of misfolded or mislocalized polypeptides. This is one of the antibodies used to confirm the that all three proteins were associated with gp78.

Potential Commercial Applications: Competitive Advantages:
  • This is a research tool that may be used to study protein quality control in mammalian cells
  • May be of use in creating novel anti-retroviral treatments
 
  • A novel, robust mechanism to model mammalian cell protein integrity


Inventors:

Yihong Ye (NIDDK)  ➽ more inventions...


Intellectual Property:
Research Material - Patent protection is not being pursued for this technology.

Publications:
Wang Q, et al. A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation. Mol Cell. 2011 Jun 24;42(6):758-70. PMID: 21636303

Licensing Contact:
Betty Tong, Ph.D.
Email: tongb@niddk.nih.gov
Phone: 301-451-7836

OTT Reference No: E-077-2015/0
Updated: Sep 8, 2016