siRNA Delivery Using Hexameric Tetrahedral RNA Nanostructures for Gene Silencing
RNA interference (RNAi) is a biological response to double-stranded RNA that regulates expression of protein-coding genes and is a natural mechanism for gene silencing. Delivery of short, interfering RNA (siRNA) leads to RNAi of the targeted genes.
Researchers at the National Cancer Institute (NCI), in collaboration with researchers at the University of California, Santa Barbara (UCSB), developed a tetrahedral-shaped RNA nanoparticle for the delivery of siRNA to activate RNAi. The tetrahedral RNA nanoparticle is comprised of four RNA nanorings as the “faces” of the tetrahedral scaffold.
The tetrahedral RNA nanoparticles can contain up to twelve Dicer substrate RNA duplexes, enabling the simultaneous targeting of multiple genes with several siRNA copies.
Potential Commercial Applications: | Competitive Advantages: |
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Development Stage:
Basic (Target Identification)
Related Invention(s):
E-765-2013
Inventors:
Bruce Shapiro (NCI) ➽ more inventions...
Paul Zakrevsky (NCI) ➽ more inventions...
Luc Jaeger (UCSB) ➽ more inventions...
Intellectual Property:
Application No. 62/696,619
Collaboration Opportunity:
Licensing and research collaboration
Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515
OTT Reference No: E-075-2018
Updated: Dec 14, 2018