AAV5 Vector for Transducing Brain Cells and Lung Cells

The invention described and claimed in this patent application is related to the delivery of heterologous nucleic acids or genes to particular target cells. In particular, the application relates to methods of delivering a heterologous nucleic acid or gene of interest to particular target cells using an Adeno-Associated Virus of serotype 5 (AAV5). The particular target cells identified include the alveolar cells of the lung and cerebellar and ependymal cells of the brain. The methods described herein may be useful in carrying out gene therapy related to diseases of the brain or central nervous system and the respiratory tract.

Related Invention(s):


John Chiorini (NHLBI)  ➽ more inventions...

Beverly Davidson
Robert Kotin (NHLBI)  ➽ more inventions...

Joseph Zabner

Intellectual Property:
PCT Pat: 6,855,314 issued 2005-02-15
US Application No. 09/533,427 filed on 2000-03-22

Davidson BL, et al. PMID 10688913
Zabner J, et al. PMID 10729159

Licensing Contact:
John Devany,
Email: john.devany@nih.gov
Phone: 301-594-4090

OTT Reference No: E-072-2000-0
Updated: May 9, 2018