AAV4 Vector and Uses Thereof

The invention described and claimed in this patent application relates to the delivery of heterologous nucleic acids or genes to particular target cells. In particular, the application relates to methods of delivering a heterologous nucleic acid or gene of interest to particular target cells using Adeno-Associated Virus of serotype 4 (AAV4). The particular target cells identified are the ependymal cells of the brain. The methods described herein may be useful in carrying out gene therapy for diseases of the brain or central nervous system.

Related Invention(s):


John Chiorini (NHLBI)  ➽ more inventions...

Robert Kotin (NHLBI)  ➽ more inventions...

Brian Safer (NHLBI)  ➽ more inventions...

Beverly Davidson

Intellectual Property:
US Pat: 6,468,524 issued 2002-10-22

Davidson BL, et al. PMID 10688913

Licensing Contact:
John Devany,
Email: john.devany@nih.gov
Phone: 301-594-4090

OTT Reference No: E-071-2000-0
Updated: May 9, 2018