Establishment of Induced Pluripotent Stem Cells (iPSC) from the Thirteen-lined Ground Squirrel


The limited choice in cell types available for in vitro studies has become an obstacle in hibernation research. 

Researchers at the NAtional Eye Institute for the first time have successfully established iPSC line(s) from a mammalian hibernator, which can be potentially used to generate various cell types and tissue models for in-depth mechanistic studies of hibernation and coldness tolerance in vitro. 

Hibernation-specific features make this line a unique platform and valuable tool for inspiring novel pharmacological strategies. For example, they can be used to bestow cold adaptability to target cells and organs derived from non-hibernating mammals, as well as translating cold-adaptive strategies into humans in clinical applications, such as neural injury or other diseases that involve cold intolerance.

Compared with human iPSC-derived neurons, GS iPSC-derived neurons are not susceptible to cold stress treatment.



Potential Commercial Applications: Competitive Advantages:
  • Research tool for studying hibernation and cold adaptability and disease modeling
  • Drug screening platform for neuronal injuries or other diseases
 
  • The first iPSC line established from small hibernators like ground squirrel
  • Potential in generating various cell types and tissue models for in-depth mechanistic studies of hibernation and coldness tolerance in vitro
  • Unique benefits in studying hibernation mechanism and cold-adaptive strategies 


Development Stage:
Pre-clinical (in vivo)

Inventors:

Wei Li (NEI)  ➽ more inventions...


Intellectual Property:

Publications:
J. Ou et al. iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications   PMID: 29576452

Collaboration Opportunity:

Licensing only


Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515

OTT Reference No: E-059-2017
Updated: Jan 26, 2021