Platform to Enhance Anti-Tumor Immunity


Cancer cells can spread to various regions in the body in a process called metastasis, which is associated with difficulty in treatment and thus reduced survival. Identifying metastatic biomarkers have been a major concern in the field of cancer diagnosis and therapy. Interestingly, research has shown that there is an increase in myeloid progenitors and myeloid cells at various stages of metastasis in tumors and tissues, as the immune system attempts to suppress cancer cells. This presents a unique opportunity for cancer immunotherapy.

Researchers at National Cancer Institute (NCI) developed a platform to culture myeloid cells from murine bone marrow cells and apheresed human peripheral blood. They genetically modified the myeloid cells to enhance anti-tumor immunity, limit inflammatory response, recruit T cells to sites of interest and specifically target, and kill tumors. The inventors used these genetically modified myeloid cells (GEMys) on a metastatic embryonal rhabdomyosarcoma tumor model. They observed an activation of immune system cells, such as mature T cells, at the site of metastases – as well as an increase in myeloid cell populations with anti-tumor properties. Furthermore, treatment of this orthotopic tumor model with GEMys reduced metastatic burden and significantly improved survival in mice. These cells can be combined with traditional immunotherapies and other cell-based strategies, such as chimeric antigen receptors, to further improve anti-tumor immunity.

The Pediatric Oncology Branch is seeking parties interested in licensing and/or co-developing this invention to commercialize the GEMys for improved cancer immunotherapy. 



Potential Commercial Applications: Competitive Advantages:
  • Cancer immunotherapy by GEMys alone or by coupling with T cell-based strategies
  • Treatment of primary solid and hematologic cancers
  • Treatment of metastatic, recurrent cancers
  • Treatment of autoimmune diseases through limiting the inflammatory response
 
  • GEMys:
    • Improved survival in an orthotopic metastatic cancer model
    • Can be further modified for enhanced functionality
    • Can be used alone or in combination with therapeutic T cells


Development Stage:
Pre-clinical (in vivo)

Inventors:

Rosandra Kaplan (NCI)  ➽ more inventions...

Sabina Kratzmeier (NCI)  ➽ more inventions...

Daniel Beury (NCI)  ➽ more inventions...

Haiying Qin (NCI)  ➽ more inventions...


Intellectual Property:
Application No. 62/803,468
Application No. PCT/US2020/17515

Publications:
Giles AJ, et al. Activation of hematopoietic stem/progenitor cells promotes immunosuppression within the premetastatic niche.  PMID 26719537
Papaspyridonos M, et al. Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation.  PMID 25924227

Collaboration Opportunity:

Licensing and research collaboration


Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515

OTT Reference No: E-053-2019
Updated: Sep 22, 2020