Hspa2 Knockout Mice for Study of Spermatogenesis and Male Infertility


HSPA2 is a member of the HSP70 family of heat-shock proteins that serve as molecular chaperones. Researchers discovered that HSPA2 protein is expressed in spermatogenesis during the meiotic phase. Spermatogenic cells lacking the HSPA2 protein arrest in mid-meiosis and undergo apoptosis. HSPA2 is present in the synaptonemal complex of wild-type mice and the chromosomes fail to separate in HSPA2-deficient mice (previously known as Hsp70-2-/- mice), suggesting that HSPA2 is required for the chromosomal events of meiosis such as synapsis, crossing over, or recombination.

Researchers at NIEHS developed a knockout strain of mice in which the heat shock protein gene (Hspa2) is disrupted. This mouse model is useful in studying the process of spermatogenesis and the influence of various environmental toxins or drugs on sperm production and male infertility.

Potential Commercial Applications: Competitive Advantages:
  • Mouse model to study spermatogenesis and male infertility
  • Mouse model to study meiosis or the roles of heat-shock proteins in general
  • Mouse model to evaluate effects of meiosis-disrupting agents on meiotic recombination and generation of mutations transmitted to offspring
 


Development Stage:
  • In vitro data available
  • In vivo data available (animal)


Related Invention(s):
E-290-2011-0


Inventors:

Edward Eddy (NIEHS)  ➽ more inventions...


Intellectual Property:
Research Tool — Patent protection is not being pursued for this technology.

Publications:
Dix DJ, et al. PMID 8622925

Collaboration Opportunity:

The NIEHS is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize this mouse strain. For collaboration opportunities, please contact Sharon Soucek, Ph.D. at sharon.soucek@nih.gov.


Licensing Contact:
Vidita Choudhry, Ph.D.
Email: vidita.choudhry@nih.gov
Phone: 301-594-4095

OTT Reference No: E-052-2011-0
Updated: Sep 4, 2020