Treatment of GPR101-Related, Growth Hormone-Related Disorders Such as Gigantism, Dwarfism or Acromegaly
Microduplications of the GPR101 gene (located on chromosome Xq26.3 and encodes a G-protein coupled receptor) can result in an excess of growth hormone causing gigantism, that has an onset in early childhood. It is also associated with the growth of sporadic growth hormone producing adenomas in some patients with acromegaly.
Current therapies (such as surgical resection of tumors or treatment with somatostatin analogs) for acromegaly, gigantism and other disorders of pituitary hormone hypersecretion can be ineffective, thereby creating a need for alternative therapies in this space.
The inventors at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) have developed a cell line that stably over-expresses GPR101.
Agents which inhibit the expression the GPR101-encoded protein or the biological activity of the protein can be used to treat gigantism.
Alternatively, agents that increase expression of the GPR101-encoded protein or the biological activity of the protein can be used:
- To treat dwarfism and short stature and
- To increase the body mass of livestock.
The NICHD seeks licensing and/or co-development research partners to collaborate on the identification and characterization of GPR101 inhibitors (antagonists and inverse agonists) and agonists with the goal of identifying agents to treat gigantism, acromegaly or dwarfism.
Potential Commercial Applications: | Competitive Advantages: |
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Development Stage:
Basic (Target Identification)
Inventors:
Constantine Stratakis (NICHD) ➽ more inventions...
Fabio Faucz (NICHD) ➽ more inventions...
Giampaolo Trivellin (NICHD) ➽ more inventions...
Albert Beckers () ➽ more inventions...
Adrian Daly () ➽ more inventions...
Intellectual Property:
U.S. Filed Application No. PCT/US2015/060442
Publications:
Beckers A et al. X-linked acrogigantism syndrome: clinical profile and therapeutic responses. PMID 25712922
Iacovazzo D et al. Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic study. DOI 10.1186/s40478-016-0328-1
Trivellin G et al. Characterization of GPR101 transcripts structure and expression patterns. PMID 27282544
Trivellin G et al. Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. PMID 25470569
Collaboration Opportunity:
Licensing and research collaboration
Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515
OTT Reference No: E-039-2016
Updated: Jan 3, 2019