Broadly Protective Influenza Vaccine Comprising a Cocktail of Inactivated Avian Influenza Viruses

There is a great need for broadly protective, “universal” influenza virus vaccines given the antigenic drift and shift of influenza viruses and the variable protective efficacy of the current influenza vaccines. This technology relates to a broadly protective, “universal” influenza vaccine candidate composed of a cocktail of different low pathogenicity avian influenza virus subtypes inactivated by betapropiolactone (BPL). Vaccinating animals with BPL-inactivated whole virus vaccine comprising influenza virus strains belonging to four or more different low pathogenicity avian influenza hemagglutinin subtypes, intranasally or intramuscularly, provided extremely broad protection and heterosubtypic protection to lethal challenge with influenza viruses in both mice and ferrets. This influenza vaccine technology has a great potential to offer broad protection against both seasonal and pandemic-potential influenza viruses.

This technology is available for licensing for commercial development in accordance with 35 U.S.C. § 209 and 37 CFR Part 404.

Potential Commercial Applications: Competitive Advantages:
  • Vaccine against viruses
  • Vaccines against influenza virus
  • Universal influenza virus vaccine
  • Broad protection to both seasonal and pandemic-potential influenza viruses
  • Easy and cost-effective inactivation method
  • Effective immune response due to the use of authentic viral antigens
  • Animal data available


Jeffery Taubenberger (NIAID)  ➽ more inventions...

Louis Schwartzman (NIAID)  ➽ more inventions...

Intellectual Property:
US Application No. 62/620,051
PCT Application No. PCT/US2019/014220
US Application No. 16/963,718

Collaboration Opportunity:

The National Institute of Allergy and Infectious Diseases is also seeking statements of capability or interest from parties interested in collaborative research. NIAID would like a prospective collaborator to have the capacity to generate clinical grade materials and perform clinical studies. NIAID will consider executing a Confidentiality Agreement with a prospective collaborator to facilitate receipt of a Capability Statement if requested. For collaboration opportunities, please contact Jenish Patel, PhD at or 240-669-2894.

Licensing Contact:
Elizabeth Pitts,
Phone: 240-669-5299

OTT Reference No: E-033-2018-0
Updated: Jul 6, 2020