Novel Anti-HIV Compounds Using Peptides or Peptide Mimetics

The subject invention describes a new class of compounds (such as peptides or mimetics) that target viral RNAs and inhibit the viral life cycle by blocking the viral recognition process. More specifically, these compounds are the first against an RNA Target - currently there are no clinical drugs against RNA targets in the treatment of any type of human disease. Anti-HIV drugs currently on the market are complicated by the development of resistance and substantial side-effects; however, these compounds would unlikely develop any side effects because of their very high specificity against only viral RNA. In addition, these compounds may be further linked to a detectable label. Thus, these compounds have the potential to be used as a new class of systemic drugs for the treatment of HIV infection and to be developed into diagnostic kits or devices.

Potential Commercial Applications: Competitive Advantages:
  • Anti-viral HIV therapeutic
  • HIV Diagnostic
  • New class of compound
  • Inhibits the viral recognition process and nuclear export activity
  • High specifity only to HIV RNA
  • Ease of permeability through cell membrane because compound is positively charged.

Development Stage:
Discovery (Lead Identification)

Related Invention(s):


Yun-Xing Wang (NCI)  ➽ more inventions...

Liu Yu (NCI)  ➽ more inventions...

Ping Yu (NCI)  ➽ more inventions...

Ina O'Carroll (NCI)  ➽ more inventions...

Intellectual Property:
US Provisional Application No. 61/894,849

Fang X, et al. PMID 24243017

Collaboration Opportunity:

Licensing only

Licensing Contact:
John Hewes, Ph.D.
Phone: 240-276-5515

OTT Reference No: E-019-2014
Updated: Jul 19, 2018