Use of Antihistamine Compounds for the Treatment of Hepatitis C Virus


The vast majority of people infected with Hepatitis C Virus (HCV) will have chronic infection. Over decades, this can lead to liver disease and liver cancer. In fact, HCV infection is the leading cause of liver transplants in the U.S. Several new drugs have recently come into the market that will likely change the HCV treatment paradigm. However, the effectiveness of these new drugs can vary depending on the HCV genotype. Thus, there is still the need for additional new therapeutics against HCV.

The subject technology are small molecule compounds identified using a novel cell-based high throughput assay of HCV infection. The compounds are antihistamines that show potent antiviral properties against HCV. One advantage of these compounds is that they are already on the market for the treatment of allergic reactions and, thus, have been used extensively in humans and have excellent safety profiles with known pharmaceutical properties. The subject technology can also potentially be used in combination with other HCV therapeutics.

Potential Commercial Applications: Competitive Advantages:
  • Prevention or treatment of HCV infection.
     
    • These compounds are already on the market and, thus, have known safety profiles and pharmaceutical properties.


    Development Stage:
    • Early-stage
    • In vitro data available


    Inventors:

    Tsanyang (Jake) Liang (NIDDK)  ➽ more inventions...

    Wei Zheng (NCATS)  ➽ more inventions...

    Shanshan (Melissa) He (NIDDK)  ➽ more inventions...

    Zongyi Hu (NIDDK)  ➽ more inventions...


    Intellectual Property:
    PCT Pat: - issued -
    US Application No. 15/039,781 filed on 2016-05-26
    US Application No. 61/909,414 filed on 2013-11-27

    Licensing Contact:
    Vladimir Knezevic, M.D.
    Email: vlado.knezevic@nih.gov
    Phone: 301.443.5560

    OTT Reference No: E-011-2014-0
    Updated: Apr 18, 2017