Anti-Plasmodium Compositions and Methods of Use


The present invention comprises peptides/antibodies specific for the binding proteins of Plasmodium, a parasite responsible for malaria, hence in effect blocking the parasite’s binding to the erythrocytes. Also included are methods for their use in preventing, diagnosing or treating the related infections.

Although malaria is virtually eradicated in the United States, it continues to be one of the most serious infectious diseases in the world, killing millions of people each year in the countries throughout Africa, Asia and Latin America. In fact, over 41% of the world population lives in the regions affected by malaria. In vitro studies using the antibodies described in the current technology showed ~80% reduction in the number of blood cells infected with Plasmodium parasite. Infectivity studies using peptides demonstrated that they are also specifically able to prevent binding of parasites to blood cells. The claimed antibodies and peptides can also be used for immunization of humans and animals, or for development of diagnostic kits capable of detecting the presence, localization and quantity of the Plasmodium parasites in tissues and cells.

Potential Commercial Applications: Competitive Advantages:
  • Diagnostics development
  • Vaccines development
 


Inventors:

David Narum


Intellectual Property:
U.S. Pat: 2004201615 issued 2007-05-11
U.S. Pat: 7,025,961 issued 2006-04-11
PCT Application No. PCT/US00/005820

Publications:
Sim BK, et al. PMID 11471569
Narum DL, et al. PMID 10722589
Liang H, et al. PMID 10816512
Tolia NH, et al. PMID 16051144
Maier AG, et al. PMID 12469115
Narum DL, et al. PMID 11814568
Mayer DCG, et al. PMID 12461087

Collaboration Opportunity:

The NIAID is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize "Anti-Plasmodium Compositions and Methods of Use." Please contact Dana Hsu at 301-496-2644 for more information.


Licensing Contact:
David (Po-Lung) Yang, Ph.D.
Email: polung.yang@nih.gov
Phone: 301-496-2644

OTT Reference No: E-004-2004-2
Updated: May 24, 2016