Technology ID

Enzymatically-Active RNA-Dependent RNA Polymerase From a Human Norovirus (Calicivirus)

Linked ID
Gael Belliot (NIAID)
Lisbeth Kim Green (NIAID)
Stanislav Sosnovtsev (NIAID)
Lead Inventors
Gael Belliot (NIAID)
Lisbeth Kim Green (NIAID)
Stanislav Sosnovtsev (NIAID)
Research Materials
Therapeutic Areas
Infectious Disease
The noroviruses (formerly known as “Norwalk-like viruses”) are associated with gastroenteritis outbreaks, affecting large numbers of individuals each year. Emerging data are supporting their increasing recognition as important agents of diarrhea-related morbidity and mortality. The frequency with which noroviruses are associated with gastroenteritis as “food and water-borne pathogens” has led to the inclusion of caliciviruses as Category B Bioterrorism Agents/Diseases. Because the noroviruses cannot be propagated by any means in the laboratory, an important strategy in their study is to development of molecular biology-based tools and replication systems. This invention reports the isolation of the first recombinant, enzymatically-active proteinase and RNA dependent RNA polymerase (RdRp) complex for a human norovirus. This enzyme should facilitate studies aimed at developing therapeutic drugs for norovirus disease.

Request More Info

Licensing Contact