Technology ID
E-276-2003-0

HIV-Dependent Expression Vector

Linked ID
TAB-807
Inventors
Jon Marsh (NIMH)
Yuntao Wu (NIMH)
Lead Inventors
Yuntao Wu (NIMH)
Co-Inventors
Jon Marsh (NIMH)
Applications
Therapeutics
Therapeutic Areas
Infectious Disease
ICs
NIMH
This invention provides a DNA construct that can be useful for both diagnostics and AIDS therapeutics. The construct can be incorporated into a retrovirus or into a cell line. This construct mediates the expression of a selected gene in the presence of HIV replication, but is silent in the absence of HIV. The cell line with the incorporated construct can be used as an indicator line for the presence of replication-competent HIV. The virus containing the construct can be used to co-infect a population of HIV-infected cells. If the construct-encoded gene is a reporter, it would specifically identify cells that are infected with HIV. If the construct-encoded gene is a cytotoxin, it would specifically kill cells that are HIV-infected. This invention may offer a novel approach to HIV elimination, as well as detection of HIV infected cells or the presence of cell-free infectious HIV.

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