Technology ID
E-233-2017-0

Alpha-Synuclein RT-QuIC: An Ultrasensitive Assay for the Detection of Alpha-Synuclein Seeding Activity Associated with Synucleinopathies

Linked ID
TAB-3406
Inventors
Andrew Hughson (NIAID)
Bradley Groveman (NIAID)
Byron Caughey (NIAID)
Christina Groveman (NIAID)
Lynne Raymond (NIAID)
Lead Inventors
Byron Caughey (NIAID)
Co-Inventors
Andrew Hughson (NIAID)
Bradley Groveman (NIAID)
Christina Groveman (NIAID)
Lynne Raymond (NIAID)
ICs
NIAID
Commercial Applications
  • Pre-mortem diagnosis of synucleinopathies, including Parkinson’s disease and Lewy-body dementia
  • A monitor of the disease progression of dementia and synucleinopathies
  • Clinical trial / drug development companion diagnostic
Main site https://www.federalregister.gov/documents/2020/03/05/2020-04534/government-owned-inventions-availability-for-licensing PDF https://www.govinfo.gov/content/pkg/FR-2020-03-05/pdf/2020-04534.pdf
Competitive Advantages
  • Uses a consistent, concentrated source of truncated alpha-synuclein protein substrate
  • Capable of disease detection prior to onset of symptoms
  • Rapid and economical

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