Technology ID
E-124-2012-0

Fgfr2 Knockout (Fgfr2tm1Cxd) Mouse Model for Developmental Biology Studies

Linked ID
TAB-2419
Inventors
Chuxia Deng (NIDDK)
Lead Inventors
Chuxia Deng (NIDDK)
Development Status
Pre-clinical
Applications
Research Materials
ICs
NIDDK
Commercial Applications
  • Mouse model to study developmental biology.
FGFR2 knockout is an embryonic lethal mutation and blocks limb bud initiation.

Fibroblast Growth Factor Receptor 2 (FGFR2) is a high affinity receptor for several members of the FGF family. The FGFR2 gene was inactivated by deleting the entire immunoglobulin-like domain of the receptor which is critical for FGF binding and FGFR2 activity. Embryos that lack this domain die at E10-11.5 owing to a failure in chorioallantoic fusion or placental formation. The deletion also blocks limb bud initiation, establishing FGFR2 as the major receptor that mediates FGF signals during limb induction.

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