Technology ID
E-118-2012-0

UTX LoxP Mouse Model for Oncology Research

Linked ID
TAB-2413
Inventors
Kai Ge (NIDDK)
Lead Inventors
Kai Ge (NIDDK)
Development Status
Pre-clinical
Applications
Research Materials
Therapeutic Areas
Oncology
ICs
NIDDK
Commercial Applications
Mouse model for Oncology research.
UTX-flox. Conditional knockout mice for the histone demethylase UTX (Kdm6a) conditional knockout will help understand its role as a tumor suppressor.

Di- and tri-methylations on histone H3 lysine 27 (H3K27me2 and H3K27me3) are epigenetic marks for gene repression. UTX (ubiquitously transcribed X chromosome protein), also known as Kdm6a (lysine (K)-specific demethylase 6a) is a histone demethylase that specifically removes H3K27me2 and H3K27me3. UTX knockout mice are embryonic lethal, so we have generated UTX conditional knockout mice (UTX-flox) in which exon 24 is flanked with loxP sites. UTX has been found to be a tumor suppressor gene mutated in a wide variety of human cancers. The UTX-flox mice provide a valuable tool to study how UTX functions as a tumor suppressor and as an epigenetic regulator of gene expression.

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