Technology ID
E-111-2012-0

Stat1LoxP (Stat1 tm1Mam ) Mouse Model for Oncology and Immunology Studies

Linked ID
TAB-2406
Inventors
Lothar Hennighausen (NIDDK)
Lead Inventors
Lothar Hennighausen (NIDDK)
Development Status
Pre-clinical
Applications
Research Materials
Therapeutic Areas
Oncology
ICs
NIDDK
Commercial Applications
Oncology
Immunology
Selective inactivation of Stat1 in mammary cells indicates that its effect as a tumor suppressor in breast is direct.

STAT1 is considered a tumor suppressor, but it is not known if this effect occurs directly in mammary cells or secondarily by disrupting interferon signaling through the JAK/STAT1 pathway to induce immune responses. ERBB2/neu-induced breast cancer appeared sooner in mice lacking STAT1 only in mammary cells than in wild-type mice, indicating that STAT1 tumor suppression was intrinsic to mammary cells and not secondary to an induced immune response.

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