Metallic Nanoparticles for Photothermal Therapy
Ultra-sensitive Diagnostic Detects fg/mL-pg/mL Pathogen/Disease Protein by Visual Color Change
Octopod (8-Pointed Star) Iron Oxide Nanoparticles Enhance MRI T2 Contrast
Microscopy System for Distinguishing Stimulated Emissions as a Means of Increasing Signal
A Microfluidic Flow-Through Immunoassay for a Simultaneous Detection of Multiple Proteins in a Sub-Microliter Biological Sample
The device consists of a series of channels that are connected via communication ports for sample flow. The channels can be individually loaded with detection reagents via portals at their ends.
Isotropic Generalized Diffusion Tensor MRI
Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have developed a method implemented as pulse sequences and software to be used with magnetic resonance imaging (MRI) scanners and systems. This technology is available for licensing and commercial development. The method allows for measuring and mapping features of the bulk or average apparent diffusion coefficient (ADC) of water in tissue – aiding in stroke diagnosis and cancer therapy assessment.
Resolution Doubling with Digital Confocal Microscopy
This technology includes a microscopy method that reduces the speed penalty at least 1000-fold, while retaining resolution improvement. A Digital mirror device (DMD) or sweptfield confocal unit is used to create hundreds to thousands of excitation foci that are imaged to a sample mounted in a conventional microscope and record the resulting emissions on an array detector. Detection of each confocal spot is done in our proprietary software, as is the processing and deconvolution that is used for a 2x resolution enhancement.
Instant Total Internal Reflection Fluorescence/Structured Illumination Microscopy (instant TIRF/SIM)
This technology includes a method which enables high-speed, super-resolution microscopy at a very high signal-to-noise ratio (SNR), for biological applications within ~200 nm (the evanescent wave decay length) of a coverslip surface. Instant TIRF/SIM may be implemented simply by modifying and adding to the excitation optics that are already present within a conventional instant SIM design. We enforce TIRF excitation by removing all wave vectors that propagate into the objective lens at sub-critical angles.
Multiview Super-resolution Microscopy System and Methods for Research and Diagnostic Applications
This technology includes a microscopy technique that combines the strengths of multiview imaging (better resolution isotropy, better depth penetration) with resolution-improving structured illumination microscopy (SIM). The proposed microscope uses a sharp line-focused illumination structure to excite and confocally detect sample fluorescence from 3 complementary views.