Product Showcase

An isolated protein of approximately 23,000 daltons in size that binds to metalloproteinases, and is potentially useful for the detection metalloproteinases.

Features:

Useful for SDS-PAGE/immunoblot standard and inhibition studies.

Inventors:

W. Stetler-Stevenson

HHS Institute/Agency:

NCI

Licensee:

Calbiochem-Novabiochem Corp.

Market Launch:

2001

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1992

Product Name:

Antibodies for carcino-embryonic antigen (CEA)

Use:

Marketed as a immunohistochemical research reagent useful for the detection and/or study of various cancers

HHS Contribution:

Developed the ATCC cell line designed Col-1

Features:

Does not react with normal colon tissue

Inventors:

J. Schlom

HHS Institute/Agency:

NCI

Licensee:

Zymed Laboratories, Inc.

Market Launch:

1992

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2004

Product Name:

Antibodies to Human Cytochrome P450 2C19

Use:

Selectively and potently inhibits CYP2C19

HHS Contribution:

Discovered agents that bind and inhibit human cytochrome p450 2C19

Features:

Human CYP2C19 Immunogen, raised in mice

Inventors:

H. Gelboin, F. Gonzalez

HHS Institute/Agency:

NCI

Licensee:

Discovery Labware, Inc.

Market Launch:

2004

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1993

Product Name:

Antibody 11/14 against T and B cells

Use:

Reacts with T and B lymphocytes

HHS Contribution:

Established a rat IgG2a anti-mouse and IgM-producing hybridomas in mouse B and T cells

Features:

To stain lymphocytes, dendritic cells and macrophages

Inventors:

G.Laszlo, K. Hathcock, R. Hodes

HHS Institute/Agency:

NCI

Licensee:

BD Biosciences - BD PharMingen

Market Launch:

1993

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1998

Product Name:

Antibody to Human Cytochrome P450-1A2

Use:

These polyclonal antisera inhibit both CYP1A1 and CYP1A2. CYP1A2 is specific for liver

HHS Contribution:

Provided antibodies that bind and inhibit cytochrome P450 1A2.

Features:

The product immunogen is rat CYP1A2.

Inventors:

H. Gelboin

HHS Institute/Agency:

NCI

Licensee:

Becton, Dickinson and Company

Market Launch:

1998

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1998

Product Name:

Antibody to Human Cytochrome P450-2A6

Use:

Potently inhibits CYP2A6, yielding up to 90% of the same human liver microsomal

HHS Contribution:

Discovered monoclonal antibodies and other binding agents to human cytochrome P450 2A6 that have advantageous properties.

Features:

Does not inhibit other human cytochrome p450s

Inventors:

H. Gelboin

HHS Institute/Agency:

NCI

Licensee:

Gentest Corporation

Market Launch:

1998

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2000

Product Name:

Autoimmunity Panel 6

Use:

Detects the presence of specific autoantibodies to help diagnose autoimmune disorders

HHS Contribution:

Developing an effective method to diagnose autoimmune disorders in mammals using recombinant enzymes

Features:

Simultaneously screens for six nuclear antibodies with superior precision and accuracy

Inventors:

N. Raben

HHS Institute/Agency:

NIAMS

Licensee:

GenBio

Market Launch:

2000

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2000

Product Name:

BIOMAX Multi-Blot Kit for Protein Gels

Use:

Simple and rapid method for comprehensive molecular analysis

HHS Contribution:

Method for production of Layered Expression Scans for tissue and cell samples

Features:

Technology Council of Maryland 2002 Bioscience Product of the Year

Inventors:

M. R. Emmert-Buck

HHS Institute/Agency:

NCI

Licensee:

20/20 Gene Systems, Inc.

Market Launch:

2000

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2001

Product Name:

BRACAnalysis®

Use:

Predictive test for risk of breast and ovarian cancer

HHS Contribution:

Isolation and cloning of human breast cancer 1 gene (BRCA 1)

Features:

Current standard of care for identifying hereditary breast and ovarian cancer

Inventors:

M. Skolnic and R. Weisman

HHS Institute/Agency:

NIEHS

Licensee:

Myriad Genetic Laboratories

Market Launch:

2001

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2002

Product Name:

Breast cancer monoclonal antibody

Use:

Markers used for identifying breast cancer cells

HHS Contribution:

Process for Producing Monoclonal Antibodies Reactive with Human Breast Cancer

Features:

Help target uses of Breast cancer susceptibilty genes

Inventors:

J. Schlom, D. Colcher, M. Nuti, P. Hand, F. Austin

HHS Institute/Agency:

NCI

Licensee:

BD Biosciences - BD PharMingen

Market Launch:

2002

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1994

Product Name:

c-erbB-2 (her2-neu) Test

Use:

Used to test for her2-neu oncogene associated with lymph node metastasis

HHS Contribution:

used for diagnostic and therapeutic purposes for her2-neu gene

Features:

Patients with an over-expression of the resulting protein are good candidates for the drug Herceptin

Inventors:

C. King

HHS Institute/Agency:

NCI

Licensee:

Schering AG

Market Launch:

1994

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1998

Product Name:

c-erbB-3 Oncoprotein marker

Use:

Recognizes an epitope in the cytoplasmic domain of the human c-erbB-3 oncoprotein

HHS Contribution:

Sequenced DNA segment encoding a gene the Epidermal Growth Factor Receptor (erbB-3)

Features:

Expression of c-erbB-3 oncoprotein has appeared in chronic pancreatitis, endocrine pancreatic cancer and in tumors of gastro-intestinal tract

Inventors:

M. Kraus, S. Aaronson

HHS Institute/Agency:

NCI

Licensee:

Novocastra Laboratories, Ltd.

Market Launch:

1998

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2005

Product Name:

c-Kit pharmDx™ Control Slides (Mouse)

Use:

c-kit protein expression levels are used for testing quality control of assay kit

HHS Contribution:

Development of P815 murine mast cell line

Features:

c-Kit pharmDx assay kit used in differential diagnosis of gastrointestinal stromal tumors

Inventors:

M. Potter

HHS Institute/Agency:

NCI

Licensee:

Dako Denmark A/S

Market Launch:

2005

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1987

Product Name:

CA72-4 RIA

Use:

Detection kit used to evaluate TAG72 serum levels in patients with gastric and other digestive tract cancers

HHS Contribution:

Developed process for producing monoclonal antibodies reactive with human breast cancer

Features:

Uses two monoclonal antibodies to target TAG-72 antigen

Inventors:

J. Schlom

HHS Institute/Agency:

NCI

Licensee:

Fujirebio Diagnostics, Inc.

Market Launch:

1987

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2000

Product Name:

CAK1 Monoclonal Antibody

Use:

Identify and trace specific cells or molecules in an organism

HHS Contribution:

Developed murine monoclonal antibody K1

Features:

Reacts with epithelial mesothelioma but no with lung adenocarinoma

Inventors:

M. Willingham, K. Chang, I. Pastan

HHS Institute/Agency:

NCI

Licensee:

Signet Laboratories, Inc.

Market Launch:

2000

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2000

Product Name:

Calcineurin Antibodies

Use:

Antibodies used to target a protein phosphatase that plays a role in immunosupression

HHS Contribution:

Developed Calcineurin Antibodies

Features:

Products include polyclonal antibodies designated RACalpha1, RACbeta2, and Hbak as well as purified bovine brain calcineurin

Inventors:

C. Klee, S. Li, C. Saddig, A. Stump

HHS Institute/Agency:

NCI

Licensee:

Upstate Biotechnology, Incorporated

Market Launch:

2000

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1998

Product Name:

Calypte® HIV-1 BED Incidence EIA

Use:

Measures time since HIV-1 infection occurred.

HHS Contribution:

Method of culturing HIV and assays for detection of infection.

Features:

First test of its kind

Inventors:

R. Gallo and L. Montagnier

HHS Institute/Agency:

NCI

Licensee:

Calypte Biomedical Corporation, Inc.

Market Launch:

1998

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1998

Product Name:

Cambridge Biotech HIV-1 Western Blot Kit

Use:

Confirmation of antibodies to HIV-1 in human serum and plasma

HHS Contribution:

Recombinant HIV envelope proteins for detection assays

Features:

First in vitro diagnostic western blot test

Inventors:

T. Papas

HHS Institute/Agency:

NCI

Licensee:

Maxim Biomedical , Inc.

Market Launch:

1998

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1997

Product Name:

CapSure Cap

Use:

Precisely dissects cancerous cells from biopsies for study

HHS Contribution:

Collaborative development of the technology

Features:

First device of its kind

Inventors:

R. Bonner

HHS Institute/Agency:

NICHD

Licensee:

Arcturus Engineering, Inc.

Market Launch:

1997

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2003

Product Name:

Carcinoembryonic Antigen

Use:

Detects early foci of gastric carcinoma and distinguishes pulminary adenocarcinomas from mesothelioma

HHS Contribution:

Provided COL-1 antibodies that keeps CEA binding affinity

Features:

COL-1 clone shows no detectable reactivity with other CEA genes.

Inventors:

J. Schlom

HHS Institute/Agency:

NCI

Licensee:

Biocare Medical, LLC

Market Launch:

2003

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1998

Product Name:

cDNA Libraries/Creator™ SMART™ cDNA Library Construction Kit

Use:

Designed to clone full-length cDNA into a plasmid vector, pDNR-Lib

HHS Contribution:

Created an improved method for the construction of directionally cloned cDNA Libraries from microdissected cells

Features:

The Creator SMART cDNA Library Construction Kit provides enough reagents to construct seven cDNA libraries.

Inventors:

Elise C. Kohn, Michael R. Emmert-Buck

HHS Institute/Agency:

NCI

Licensee:

Clontech Laboratories, Inc

Market Launch:

1998

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1998

Product Name:

Certiva®

Use:

Combined diphtheria, tetanus and acellular pertussis vaccine for use in infants and children

HHS Contribution:

Culturing whooping cough bacterium and inactivating its toxin for immunization

Features:

Reduced side-effects from vaccine formulation

Inventors:

R. Sekura

HHS Institute/Agency:

NICHD

Licensee:

Baxter International, Inc.

Market Launch:

1998

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2007

Product Name:

Cervarix®

Use:

Vaccine for human papilloma virus (HPV) to protect from cancers

HHS Contribution:

Non-infectious HPV-like particles for immunization

Features:

First EU approved vaccine against cervical cancer and genital warts

Inventors:

D. Lowy

HHS Institute/Agency:

NCI

Licensee:

GlaxoSmithKline

Market Launch:

2007

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1991

Product Name:

CHAPS

Use:

Useful for solubilizing animal cell membrane proteins

HHS Contribution:

Development of a stable chemical for disolving cell membrane proteins

Features:

The most popular reagent used in labs to dissolve cell membrane proteins

Inventors:

L. Hjelmeland

HHS Institute/Agency:

NICHD

Licensee:

Sigma-Aldrich

Market Launch:

1991

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2006

Product Name:

Click-iT™ O-GlcNAc Enzymatic Labeling System

Use:

It provides a highly sensitive and efficient method for the in-vitro modification of O-GlcNAc modified proteins

HHS Contribution:

Discovered that the enzymatic activity of (1,4)-galactosyltransferase can be altered so that the enzyme can make chemical bonds more easily.

Features:

Labeling and detection can be completed in less than 24 hours.

Inventors:

P. Qasba, B. Ramakrishnan

HHS Institute/Agency:

NCI

Licensee:

Invitrogen Corporation

Market Launch:

2006

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2001

Product Name:

Clones AD1, BC4, AA4

Use:

Biological materials used in research and treatment development for allergies, cancer, and parasites

HHS Contribution:

Producing the antibodies directed at certain cells and other antibody fractions of rats

Features:

Controllable and reproducible clones suited for flow cytometry, immunoprecipitation, and frozen section procedures

Inventors:

R. Sirangania

HHS Institute/Agency:

NIDCR

Licensee:

BD PharMingen

Market Launch:

2001

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2002

Product Name:

Cultrex® Basement Membrane Extract

Use:

Ideal for cell invasion, tissue regrowth, and cancer development studies

HHS Contribution:

Extracting and preparing a biologically active membrane complex from mouse cancer cells

Features:

Tested and cleared for 31 pathogens that include viruses, bacteria, and mycoplasma

Inventors:

H. Kleinman

HHS Institute/Agency:

NIDCR

Licensee:

Trevigen, Inc.

Market Launch:

2002

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2005

Product Name:

Cultrex® DIVAA™ Angiogenesis Activation Assay Kit

Use:

Designed for assessing angiogenesis activation

HHS Contribution:

Discovered a method of performing an in vivo angiogenesis assay which involves the use of a matrix material

Features:

The Kit controls the site for angiogenesis, increasing reproducibility, and conserving test compounds

Inventors:

G. Martin

HHS Institute/Agency:

NCI

Licensee:

Trevigen, Inc.

Market Launch:

2005

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2005

Product Name:

Cultrex® DIVAA™ Angiogenesis Assay Kit

Use:

Designed for assessing angiogenesis activation

HHS Contribution:

Discovered a method of performing an in vivo angiogenesis assay which involves the use of a matrix material

Features:

The Kit controls the site for angiogenesis, increasing reproducibility, and conserving test compounds

Inventors:

G. Martin

HHS Institute/Agency:

NCI

Licensee:

Trevigen, Inc.

Market Launch:

2005

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2005

Product Name:

Cultrex® DIVAA™ Angiogenesis Starter Kit

Use:

Angioreactor optimizes sensitivity and provides a more controlled experiment

HHS Contribution:

Discovered a method of performing an in vivo angiogenesis assay which involves the use of a matrix material

Features:

The Kit controls the site for angiogenesis, increasing reproducibility, and conserving test compounds

Inventors:

G. Martin

HHS Institute/Agency:

NCI

Licensee:

Trevigen, Inc.

Market Launch:

2005

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2005

Product Name:

Cultrex® DIVAA™ Inhibition Kit

Use:

Designed for assessing angiogenesis inhibition

HHS Contribution:

Discovered a method of performing an in vivo angiogenesis assay which involves the use of a matrix material

Features:

The Kit controls the site for angiogenesis, increasing reproducibility, and conserving test compounds

Inventors:

G. Martin

HHS Institute/Agency:

NCI

Licensee:

Trevigen, Inc.

Market Launch:

2005

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1999

Product Name:

CYP2A6 Antibody

Use:

Inhibits the CYP2A6 activity

HHS Contribution:

Discovered agents that bind and inhibit human cytochrome p450 2A6

Features:

Does not cross react with other human p450 isoforms

Inventors:

H. Gelboin

HHS Institute/Agency:

NCI

Licensee:

PanVera LLC

Market Launch:

1999

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1989

Product Name:

Detect HIV/Select HIV Kit

Use:

Screens for HIV virus

HHS Contribution:

Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and consequently, linked the HIV virus to AIDS

Features:

Faster results than ELISA Kit and this test can be performed anywhere, including mobile screening units

Inventors:

R. Gallo and L. Montagnier

HHS Institute/Agency:

NCI

Licensee:

Adaltis

Market Launch:

1989

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1992

Product Name:

Diagnostic Assays for Helicobacter (PCR tests)

Use:

Detects the presence of bacteria or viruses in different organisms

HHS Contribution:

Isolated Helicobacter hepaticus nucleic acid and provided a specific antigen.

Features:

Tests are conducted in different rooms to prevent cross contamination

Inventors:

J. Ward

HHS Institute/Agency:

NCI

Licensee:

Anmed/Biosafe, Inc.

Market Launch:

1992

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2005

Product Name:

Didanosine

Use:

Treatment of HIV infection with dideoxyinosine (generic equivalent for Videx® EC)

HHS Contribution:

Discovery and early drug development of dideoxyinosine (ddI)

Features:

Generic version of 2nd FDA approved AIDS drug

Inventors:

R. Yarchoan and H. Mitsuya

HHS Institute/Agency:

NCI

Licensee:

Barr Laboratories, Inc.

Market Launch:

2005

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1995

Product Name:

Diethylenetriamine (Nitric Oxide Adduct)

Use:

Long-acting nitric oxide donor

HHS Contribution:

Discovered complexes of nitric oxide and polyamines that are potentially useful in treating cardiovascular disorders

Features:

Controlled, long-term release of nitric oxide under physiologic conditions

Inventors:

L. Keefer

HHS Institute/Agency:

NCI

Licensee:

Sigma-R.B.I.

Market Launch:

1995

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1994

Product Name:

Diethylenetriamine NONOate (Nitric Oxide Donors)

Use:

Research tool/reagent for nonhuman investigations

HHS Contribution:

Synthesized nitric oxide donor useful for localizing antithrombotic, vasodilatory, and other nitric oxide-mediated activities

Features:

It spontaneously dissociates in a pH- dependent

Inventors:

J. Saavedra, M. Akamatsu, L. Keefer, P. Roller

HHS Institute/Agency:

NCI

Licensee:

Cayman Chemical Company

Market Launch:

1994

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2004

Product Name:

Diethylenetriamine pentaacetate

Use:

Material for the treatment for contamination of radioactive material

HHS Contribution:

Created methods utilizing the bifunctional cyclohexyl DPTA ligands

Features:

Also prevents the mixture of other ingredients in a product

Inventors:

O. Gansow

HHS Institute/Agency:

NCI

Licensee:

Macrocyclics, Inc.

Market Launch:

2004

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1996

Product Name:

Diffusion Tensor Imaging

Use:

MRI technique to help diagnose problems in the brain

HHS Contribution:

A method and system for measuring the effective diffusion tensor for spin labeled particles, and generating images

Features:

Useful in measuring the effective diffusion tensor for spin labeled particles and for generating images.

Inventors:

P. Basser, J. Mattiello, D. LeBihan

HHS Institute/Agency:

NCI

Licensee:

Covance Research Products, Inc.

Market Launch:

1996

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2005

Product Name:

Diffusion tensor MRI

Use:

Mapping white matter in brain using MRI

HHS Contribution:

Method of MRI using water movement along parallel neurons.

Features:

Unique ability to display live tissues non-invasively without injecting the patient

Inventors:

P. Basser and C. Pierpaoli

HHS Institute/Agency:

NINDS

Licensee:

Siemens Aktiengesellschaft

Market Launch:

2005

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2002

Product Name:

DPD Exon-14 Skipping mutation test

Use:

To identify Exon 14-Skipping Mutation in the DPD-gene for cancer patients.

HHS Contribution:

Devised methods and compositions useful for detecting deficiencies in dihydropyrimidine dehydrogenase (DPD) levels in humans

Features:

Could help substantially reduce health care expenses

Inventors:

F. Gonzales P. Fernandez-Salguero

HHS Institute/Agency:

NCI

Licensee:

Oncoscreen GmbH

Market Launch:

2002

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2005

Product Name:

DUALmembrane starter kits

Use:

Screen full-length integral membrane proteins in vivo

HHS Contribution:

Developed efficient directional genetic cloning system

Features:

Has a variety of easy-to-use kits to choose from

Inventors:

T. Miki, S. Aaronson

HHS Institute/Agency:

NCI

Licensee:

DUALSYSTEMS Biotech, AG

Market Launch:

2005

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1996

Product Name:

ECM Gel

Use:

This gel is used in research as a base for culturing cells

HHS Contribution:

Extracting and preparing a biologically active membrane complex from mouse cancer cells

Features:

Promotes differentiation and growth of cells in three-dimensional culture systems

Inventors:

H. Kleinman and G. Martin

HHS Institute/Agency:

NIDCR

Licensee:

Sigma Chemical Corporation

Market Launch:

1996

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1994

Product Name:

ERBB-3 Receptor

Use:

Localization, but with limited information, of nuclear ERBB-3 receptor protein

HHS Contribution:

Previous research prompted the designation of the new gene as erbB-3

Features:

Small inhibitory RNA to ERBB3 or AKT is showing promise as a therapeutic approach to treatment of lung adenocarcinoma.

Inventors:

M. Kraus, S. Aaronson

HHS Institute/Agency:

NCI

Licensee:

Oncogene Sciences, Inc.

Market Launch:

1994

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2001

Product Name:

Familial Mediterranean Fever (FMF) GenotypR™

Use:

Blood test to screen individuals with the gene for Familial Mediterranean Fever

HHS Contribution:

Identifying the gene on chromosome 16 responsible for causing Familial Mediterranean Fever

Features:

Earlier and more accurate diagnoses by detecting almost 75% of the genetic mutations associated with FMF

Inventors:

D. Kastner et al

HHS Institute/Agency:

NIAMS

Licensee:

Specialty Labs, Inc.

Market Launch:

2001

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2000

Product Name:

Familial Mediterranean Fever Testing

Use:

To screen affected individuals and carriers of FMF using cheek swabs, blood samples, or body fluid

HHS Contribution:

Identifying the gene on chromosome 16 responsible for causing Familial Mediterranean Fever

Features:

Earlier treatment participation made possible by analyzing key areas of the gene and detecting mutations in the FMF gene

Inventors:

D. Kastner et al

HHS Institute/Agency:

NIAMS

Licensee:

GeneDx, Inc.

Market Launch:

2000

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1996

Product Name:

Fibronectin Fragment

Use:

Mediate cell adhesion and promote neurite outgrowth

HHS Contribution:

Obtained evidence for significant direct effects of TSP1 on T cell responses that are involved in anti-tumor immunity

Features:

Has been located in several other heparin/heparan sulfate-binding proteins and may represent a potential binding motif for sulfated polyanions

Inventors:

D. Roberts

HHS Institute/Agency:

NCI

Licensee:

Bachem California

Market Launch:

1996

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1991

Product Name:

Fludara®

Use:

Treatment of chronic lymphocytic leukemia (CLL) for patients who did not respond to alkylating agents

HHS Contribution:

Synthesis and use of fludarabine for cancer

Features:

First treatment in a new class of highly effective chemotherapy agents (the purine analogues) for chronic lymphocytic leukemia

Inventors:

J. Montgomery

HHS Institute/Agency:

NCI

Licensee:

Schering AG

Market Launch:

1991

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2004

Product Name:

Fluorescent Pteridine-based Nucleoside analog probes

Use:

Used for various application for the study of DNA interactions

HHS Contribution:

Developed Fluorescent Pteridine Nucleotide Analogs

Features:

Provides opportunities for monitoring subtle changes in DNA structure

Inventors:

M. Hawkins, F. Balis, W. Pfleiderer

HHS Institute/Agency:

NCI

Licensee:

Fidelity Systems, Inc.

Market Launch:

2004

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1994

Product Name:

Fluorognost™ HIV-1 IFA

Use:

Detects antibodies to HIV-1 in human serum or plasma

HHS Contribution:

More sensitive and more specific than Western blotting techniques; as a result, it is sometimes used as an additional test

Features:

Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and consequently linked the HIV virus to AIDS

Inventors:

R. Gallo, L. Montganier

HHS Institute/Agency:

NCI

Licensee:

Waldheim Pharmazuetika GmbH

Market Launch:

1994

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2006

Product Name:

Gardasil®

Use:

Vaccine for human papilloma virus (HPV) to protect from cancers

HHS Contribution:

Non-infectious HPV-like particles for immunization

Features:

First FDA approved vaccine against cervical cancer and genital warts

Inventors:

D. Lowy

HHS Institute/Agency:

NCI

Licensee:

Merck Co. Inc.

Market Launch:

2006

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2002

Product Name:

GeneSeq HIV

Use:

Used to diagnose patients that have drug resistant HIV.

HHS Contribution:

Propagation of HIV in the lab and HIV proteases used for drug development.

Features:

Extensive gene database of HIV strains associated with drug resistance

Inventors:

A. Babson, A., S. Oroszlan, L. Montagnier, M. Eiden, E Berger, and C. Combadiere

HHS Institute/Agency:

NIAID

Licensee:

Monogram Biosciences

Market Launch:

2002

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1998

Product Name:

Genetic Systems HIV-1 Western Blot

Use:

Used to confirm HIV infections.

HHS Contribution:

Propagation of HIV in the lab and HIV proteases used for drug development.

Features:

Offers same-day results for faster turn around and is suited for using dried blood

Inventors:

L. Montagnier and R. Gallo

HHS Institute/Agency:

NCI

Licensee:

Bio-Rad Laboratories, Inc

Market Launch:

1998

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1993

Product Name:

GL-1 antibody against T and B cells

Use:

Reacts with T and B lymphocytes

HHS Contribution:

Established a rat IgG2a anti-mouse and IgM-producing hybridomas in mouse B and T cells

Features:

To stain lymphocytes, dendritic cells and macrophages

Inventors:

G.Laszlo, K. Hathcock, R. Hodes

HHS Institute/Agency:

NCI

Licensee:

BD Biosciences - BD PharMingen

Market Launch:

1993

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1993

Product Name:

GL-7 antibody against T and B cells

Use:

Reacts with T and B lymphocytes

HHS Contribution:

Established a rat IgG2a anti-mouse and IgM-producing hybridomas in mouse B and T cells

Features:

To stain lymphocytes, dendritic cells and macrophages

Inventors:

G.Laszlo, K. Hathcock, R. Hodes

HHS Institute/Agency:

NCI

Licensee:

BD Biosciences - BD PharMingen

Market Launch:

1993

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1997

Product Name:

Growth Arrest and DNA Damage-45

Use:

Gadd45 expression has been shown to be dependent on the tumor suppressor and p53 transcription factor

HHS Contribution:

Identified a critical role Gadd45a that protects the skin against cancer-causing damage from the sun's rays.

Features:

GADD45 is the only known x-ray responsive gene whose induction is not mediated by PKC

Inventors:

J. Hildesheim, M Anver, W Alvord, M Hollander, A Fornace

HHS Institute/Agency:

NCI

Licensee:

Zymed Laboratories, Inc.

Market Launch:

1997

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2006

Product Name:

Havrix®

Use:

Vaccine against Hepatitis A

HHS Contribution:

Propagation of Hepatitis A virus strain HM-175 in cell culture rather than animal hosts

Features:

Protects against a common virus acquired during travel

Inventors:

R. Daemer et al.

HHS Institute/Agency:

NIAID

Licensee:

SmithKline Beecham

Market Launch:

2006

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1995

Product Name:

Heat Shock Factor

Use:

HSF regulates the expression of Heat Shock Proteins

HHS Contribution:

Discovered that presence of HSF in the nucleus of a cell can be detected with specific anti-HSF antibody reagents.

Features:

A set of complete antibodies to identify the cancer cause related stress proteins including Hsp 27, Hsp 60, Hsp 70 and Hsp 90 for in vitro use

Inventors:

C. Wu

HHS Institute/Agency:

NCI

Licensee:

Stressgen Bioreagents Limited Partnership

Market Launch:

1995

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1995

Product Name:

Heat Shock Factor 1

Use:

The antibody detects heat shock factor 1 from human, mouse and rat tissues and cells.

HHS Contribution:

Discovered in vitro detection of HSF-1 in tissue culture cells

Features:

Has been successfully used in Western blot, immunoprecipitation, ELISA, and gel super shift protocols.

Inventors:

C Wu

HHS Institute/Agency:

NCI

Licensee:

Affinity BioReagents, Inc.

Market Launch:

1995

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1999

Product Name:

Heregulin-β3 (growth factor)

Use:

Used to aid the growth of certain types of cells

HHS Contribution:

Developed a method for producing Human Heregulin Growth Factor Beta

Features:

Routinely evaluated by Receptor Activation Analysis

Inventors:

J. Pierce, M. Alimandi, L. Wang

HHS Institute/Agency:

NCI

Licensee:

Upstate Biotechnology, Incorporated

Market Launch:

1999

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1995

Product Name:

HHV-6 Antibodies

Use:

Identify and trace specific cells or molecules in an organism

HHS Contribution:

Isolated Human B Lymphotropic Virus (HHV-6)

Features:

Can provide serological evidence of previous HHV-6 infection

Inventors:

S. Salahuddin, D. Ablashi, R. Gallo, S. Josephs, F. Saxinger, F. Wong-Staal

HHS Institute/Agency:

NCI

Licensee:

Advanced Biotechnologies, Inc.

Market Launch:

1995

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2000

Product Name:

HIV 1 /2 STAT-PAK® Dipstick Assay

Use:

Diagnostic tests for the rapid detection of antibodies to HIV-1 and HIV-2

HHS Contribution:

Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and consequently linked the HIV virus to AIDS

Features:

Delivers fast, accurate results to help clinical decision-making

Inventors:

R. Gallo

HHS Institute/Agency:

NCI

Licensee:

Chembio Diagnostic Systems, Inc.

Market Launch:

2000

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2000

Product Name:

HIV 8E5 (cell line)

Use:

Suited for investigations of HIV recombination in tissue culture

HHS Contribution:

Cell Line Producing AIDS Viral Antigens without Producing Infectious Viral Particles

Features:

Contain a single copy of a defective HIV provirus with a mutation

Inventors:

T. Folks, M. Martin D. Powell

HHS Institute/Agency:

NCI

Licensee:

BBI-Biotech Research Laboratories, Inc.

Market Launch:

2000

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1995

Product Name:

HIV assay

Use:

Detecting the presence of antibodies to the retrovirus associated with AIDS

HHS Contribution:

Developed terrological detection of antibodies to HTLV-III and method of production of retroviruses (HTLV-III)

Features:

Produce results that are highly accurate, reliable, and appropriate to protect the blood supply or assist in the diagnosis of HIV infection

Inventors:

R. Gallo, M. Popovic, M. Sarngadharan

HHS Institute/Agency:

NCI

Licensee:

SmithKline Beecham Pharmaceuticals

Market Launch:

1995

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2006

Product Name:

HIV lysate

Use:

Test kit used for the detection of HIV-1 in serum, plasma, or urine

HHS Contribution:

Developed a method of testing human blood for the presence of antibodies to the HIV virus using the envelope protein.

Features:

Can also help purify viral proteins

Inventors:

R. Gallo and R. Crowl

HHS Institute/Agency:

NCI

Licensee:

Maxim Biomedical Inc.

Market Launch:

2006

Back to Table of Contents

1998

Product Name:

HIV-1 lysate

Use:

Detects HIV-1 antibodies

HHS Contribution:

Serological detection of antibodies to HTLV-III in sera of patients with AIDS and pre-AIDS conditions

Features:

Can also help purify viral proteins

Inventors:

R. Gallo, M Popovic, M. Sarngadharan

HHS Institute/Agency:

NCI

Licensee:

Beacon Diagnostics, Inc.

Market Launch:

1998

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1996

Product Name:

HIV-1 p24 antigen assay

Use:

Diagnostic test for HIV

HHS Contribution:

Cell lines producing non-infectious HIV antigens

Features:

Can detect HIV only 19 days after initial exposure, six days earlier than other tests.

Inventors:

T. Folks ET al.

HHS Institute/Agency:

NIAID

Licensee:

Coulter Corporation

Market Launch:

1996

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1996

Product Name:

HIV-1 p24 ELISA kit

Use:

Diagnostic immunoassay kit for measurement of p24 protein in serum or plasma

HHS Contribution:

Produced monoclonal antibodies to HIV virus p24 proteins

Features:

Reliable and easy to use

Inventors:

M. Sarngadharan, F. di Marzo Veronese, R. Gallo

HHS Institute/Agency:

NCI

Licensee:

Coulter Corporation

Market Launch:

1996

Back to Table of Contents

1992

Product Name:

HIV-1 p24 ELISA KIT

Use:

Diagnostic kit for measurement of p24 protein in serum or plasma

HHS Contribution:

Produced HIV-1 in cell culture and developed methods of serological detection of antibodies to HIV-1.

Features:

Reliable and easy to use

Inventors:

M. Sargandharan, J. Medabalimi, S. Oroszlan, L. Montagnier and R. Crowl

HHS Institute/Agency:

NCI

Licensee:

Trinity Biotech, Plc

Market Launch:

1992

Back to Table of Contents

2000

Product Name:

HIV-1 Protease

Use:

Research reagent employed in developing treatments for Human Immunodeficiency Virus

HHS Contribution:

Utilizing recombinant methods to produce highly purified HIV-1 protease in bacteria

Features:

One of the most important targets for developing an anti-HIV-1 drug

Inventors:

S. Stahl and P. Wingfield

HHS Institute/Agency:

NIAMS

Licensee:

Veritas, Incorporated

Market Launch:

2000

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1993

Product Name:

HIV-1/2

Use:

Immunoassay for simultaneous detection of HIV p24 antigen and HIV 1/2 antibodies

HHS Contribution:

Co-discovered Human Immunodeficiency Virus 9HIV)

Features:

Easy-to-use and reliable

Inventors:

R. Gallo, et al

HHS Institute/Agency:

NCI

Licensee:

Abbott Laboratories, Inc.

Market Launch:

1993

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1992

Product Name:

Hivid®

Use:

Used in combination with antiretroviral agents for the treatment of HIV infection

HHS Contribution:

Didieoxycytidine (ddC) as inhibitor of HIV reverse-transcriptase

Features:

Third antiretroviral approved by FDA for HIV/AIDS

Inventors:

H. Mitsuya

HHS Institute/Agency:

NCI

Licensee:

Roche Laboratories, Inc.

Market Launch:

1992

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1991

Product Name:

HTLV Blot 2.4

Use:

Confirmatory test that can detect both HTLV-I and HTLV-II viruses

HHS Contribution:

Produced HTLV-1 envelope proteins in bacteria

Features:

Coated with a monoclonal antibody specific for the p24

Inventors:

S. Broder, S. Matsushita, M.Robert-Guroff

HHS Institute/Agency:

NCI

Licensee:

Genelabs

Market Launch:

1991

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1993

Product Name:

HTLV III ELISA

Use:

Screens for the presence of antibodies to HIV-1 and HIV-2.

HHS Contribution:

Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and consequently, linked the HIV virus to AIDS

Features:

Inventors:

R. Gallo, L. Montagnier

HHS Institute/Agency:

NCI

Licensee:

Genelabs

Market Launch:

1993

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1993

Product Name:

HTLV-I Tests

Use:

Screens for HTLV-1 virus

HHS Contribution:

Produced HTLV-1 envelope proteins in bacteria

Features:

Backed by world-class service and strong local support

Inventors:

S. Broder, S. Matsushita, M.Robert-Guroff

HHS Institute/Agency:

NCI

Licensee:

Roche Laboratories, Inc.

Market Launch:

1993

Back to Table of Contents

2000

Product Name:

HTLV-III antibody serological detection

Use:

Detection method used in AIDS tests

HHS Contribution:

Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and consequently, linked the HIV virus to AIDS

Features:

Coated with HTLV-III and ELISA materials

Inventors:

R. Gallo, L. Montangier

HHS Institute/Agency:

NCI

Licensee:

Intracel Corporation

Market Launch:

2000

Back to Table of Contents

1994

Product Name:

HTLV-III antibody serological detection

Use:

Detection method used in AIDS tests

HHS Contribution:

Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions

Features:

Inventors:

R. Gallo, L. Montagnier, and R. Crowl

HHS Institute/Agency:

NCI

Licensee:

Roche Laboratories, Inc.

Market Launch:

1994

Back to Table of Contents

1993

Product Name:

HTLV-III antibody serological detection

Use:

Detection method used in AIDS tests

HHS Contribution:

Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions

Features:

Coated with HTLV-III for ELISA Detection

Inventors:

R. Gallo

HHS Institute/Agency:

NCI

Licensee:

Pharmacia-Upjohn Company

Market Launch:

1993

Back to Table of Contents

1998

Product Name:

Human (hu-8845) antibody

Use:

Identify PLK enzymes in vitro

HHS Contribution:

Developed hu-1882 PLK-peptide

Features:

Specific for human PLK identification

Inventors:

D. Ferris

HHS Institute/Agency:

NCI

Licensee:

Upstate Biotechnology, Incorporated

Market Launch:

1998

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1999

Product Name:

Human Cytochrome P450 antibodies

Use:

Selectively and potently inhibits the human cytochrome p450

HHS Contribution:

mAb to human cytochrome P450, 2C8, 2C9, 2C18, and 2C19

Features:

No detection of cross reactions with other human cytochrome p450s.

Inventors:

H. Gelboin

HHS Institute/Agency:

NCI

Licensee:

Becton, Dickinson and Company

Market Launch:

1999

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1997

Product Name:

Human IL-8

Use:

Circulating human IL-8 might be a useful, clinically relevant circulating tumor protein marker due to its positive correlation with multiple physiologic variables associated with lung cancer progression

HHS Contribution:

Discovered nucleic acids encoding a novel neutrophil chemotactic factor IL-8.

Features:

There are Elisa Kits, Anti-Human Il-8, and Recombinants from which to choose from.

Inventors:

K. Matushima

HHS Institute/Agency:

NCI

Licensee:

PeproTech, Inc.

Market Launch:

1997

Back to Table of Contents

1996

Product Name:

Human Immunodeficiency Virus (HIV), p24

Use:

Reacts with and labels cells expressing p24

HHS Contribution:

Disclosed antibodies that bind very specifically to proteins associated with the HTLV-III virus

Features:

Helps study HIV antigen tissue sections.

Inventors:

R. Gallo, F. Veronese, M. Samgadharan

HHS Institute/Agency:

NCI

Licensee:

Dako Denmark A/S

Market Launch:

1996

Back to Table of Contents

1992

Product Name:

Human interleukin 1 beta (IL – 1β) antibody

Use:

Identify and trace specific cells or molecules in an organism

HHS Contribution:

Developed 3DZ cell line producing monoclonal antibody to IL-1 beta

Features:

IL-1 Beta is an important mediator of the inflammatory response

Inventors:

J. Oppenheim

HHS Institute/Agency:

NCI

Licensee:

Upstate Biotechnology, Incorporated

Market Launch:

1992

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1994

Product Name:

Human NM23 Protein & Antibodies

Use:

Used to detect NM23 in human tumors to predict the malignancy potential of such tumors

HHS Contribution:

Human NM23 DNA, protein and antibodies

Features:

NM23 is now more widely studied because of its role in metastasis suppression and oncogenesis

Inventors:

C. King, P. Steeg, L. Liotta,

HHS Institute/Agency:

NCI

Licensee:

Oncogene Sciences, Inc.

Market Launch:

1994

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1995

Product Name:

Human NM23 Proteins & Antibodies

Use:

Expression of the protein correlates with metastatic potential of tumors

HHS Contribution:

Production and Use of Human NM23 Protein and Antibodies

Features:

Inhibits differentiation, interacts with GTP-binding (GAP) proteins, autophosphorylates serine residues, and binds to DNA

Inventors:

C. King, L. Liotta, P. Steeg

HHS Institute/Agency:

NCI

Licensee:

BD Biosciences - BD PharMingen

Market Launch:

1995

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2002

Product Name:

Human p53 PTM antibodies

Use:

Research tool for studying human p53 protein functions

HHS Contribution:

Developed unpurified rabbit antisera against acetyl-human p53 (Lys 382)

Features:

Human p53 is post-translationally modified (PTM) on at least 18 sites in response to different stresses

Inventors:

B. Appella, Y. Higashimoto

HHS Institute/Agency:

NCI

Licensee:

Trevigen, Inc.

Market Launch:

2002

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2003

Product Name:

Human Thymidylate Synthase Antibody

Use:

Used for de novo synthesis of DNA and reacts specifically with human Thymidylate Synthase

HHS Contribution:

Developed the hybridoma that produces a monoclonal antibody specific for hymidylate synthase

Features:

Overexpression of Thymidylate Synthase usually leads to a shorter survival time of certain types of tumors

Inventors:

C. Liang, B. Chabner, C. Allegra, P. Johnston

HHS Institute/Agency:

NCI

Licensee:

QED Bioscience, Inc.

Market Launch:

2003

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1998

Product Name:

Human Thymidylate Synthase Antibody

Use:

Specifically reacts to human thymidylate synthase

HHS Contribution:

Developed a hybridoma that produces a monoclonal antibody specific to thymidylate synthase

Features:

Overexpression of Thymidylate Synthesis usually leads to a shorter survival time of certain types of tumors

Inventors:

C. Allegra, B. Chabner,

HHS Institute/Agency:

NCI

Licensee:

Oncotech Incorporated

Market Launch:

1998

Back to Table of Contents

1994

Product Name:

Hybridoma clone 2G9C3 kit

Use:

In vivo or in vitro use for detecting or treating human cancer

HHS Contribution:

Developed hybridoma clone 2G9C3

Features:

Engineered to produce a desired antibody in large anounts

Inventors:

L. Varesio, S. Giardina, D. Longo

HHS Institute/Agency:

NCI

Licensee:

Bayer Corporation

Market Launch:

1994

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1993

Product Name:

Hybridoma MAb13

Use:

Applications in research, diagnostics, and treatment due to its effects on cell attachment, spreading, and migration

HHS Contribution:

Producing the actual cells by fusing spleen cells and cancer cells

Features:

Antibodies specifically target human α5 β1 integrins which play a significant role in wound healing and tumor growth

Inventors:

K. Yamada

HHS Institute/Agency:

NIDCR

Licensee:

Becton, Dickinson and Company

Market Launch:

1993

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1994

Product Name:

Hybridoma MAb16

Use:

Applications in research, diagnostics, and treatment due to its effects on cell attachment, spreading, and migration

HHS Contribution:

Producing the actual cells by fusing spleen cells and cancer cells

Features:

Antibodies specifically target human α5 β1 integrins which play a significant role in wound healing and tumor growth

Inventors:

K. Yamada

HHS Institute/Agency:

NIDCR

Licensee:

Becton, Dickinson and Company

Market Launch:

1994

Back to Table of Contents

1997

Product Name:

IL-8 Protein Kit

Use:

Detection of individual cells secreting specific cytokines

HHS Contribution:

Determined solution structure of interleukin-8 (IL-8/NAP-1)

Features:

Shown to down-modulate inflammatory activity

Inventors:

M. Yamada and K. Matsushima

HHS Institute/Agency:

NCI

Licensee:

Research and Diagnostic Systems, Inc.

Market Launch:

1997

Back to Table of Contents

1996

Product Name:

Inbred miniature swine SLA haplotypes

Use:

Provides a method of inducing tolerance in a recipient mammal of a first species to a graft from a donor mammal of a second species

HHS Contribution:

Produced homozygous and recombinant miniature swine

Features:

Used as a research tool in a variety of medical and pharmacological applications

Inventors:

D. Sachs

HHS Institute/Agency:

NCI

Licensee:

Charles River Laboratories

Market Launch:

1996

Back to Table of Contents

1997

Product Name:

INNO-LIA™ HTLV I/II Score

Use:

Diagnostic test that can differentiate between HIV-1 and HIV-2

HHS Contribution:

Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and linked the HIV virus to AIDS

Features:

Incorporates recombinant proteins and synthetic peptides from HTLV I and II

Inventors:

R. Gallo, L. Montagnier

HHS Institute/Agency:

NCI

Licensee:

Innogenetics, N.V.

Market Launch:

1997

Back to Table of Contents

2001

Product Name:

Interleukin-2 Antibody

Use:

Used for the detection of IL-2 of human origin

HHS Contribution:

Disclosed a sandwich method and a kit for assaying interleukin-2 receptor (IL-2R) in a sample.

Features:

Antibodies raised against full length recombinant IL-2 of rat/human/sheep origin

Inventors:

R. Yarchoan, W. Leonard, D. Nelson,

HHS Institute/Agency:

NCI

Licensee:

Santa Cruz Biotechnology, Inc.

Market Launch:

2001

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1999

Product Name:

Interleukin-2 Receptor Antibody

Use:

Antibodies against CD25 for potential use as an immunodirected therapy to selectively attack (kill) CD25 expressing cells

HHS Contribution:

Discloses a sandwich method and a kit for assaying interleukin-2 receptor (IL-2R) in a sample.

Features:

Recognizes epitope B of the IL-2 alpha receptor of about 55 kd (1,6)

Inventors:

R. Yarchoan, W. Leonard, D. Nelson

HHS Institute/Agency:

NCI

Licensee:

Ancell Corporation

Market Launch:

1999

Back to Table of Contents

1997

Product Name:

Interleukin-8 Protein and Antibodies

Use:

Antibody reacts with the 72 and 77 amino acid forms of human IL-8

HHS Contribution:

Previously determined solution structure of interleukin-8 (IL-8/NAP-1)

Features:

No cross-reactivity with any other cytokines that were tested

Inventors:

M. Yamada and K. Matsushima

HHS Institute/Agency:

NCI

Licensee:

BD Biosciences - BD PharMingen

Market Launch:

1997

Back to Table of Contents

2005

Product Name:

iTAG MHC Mart 1 Tetramer Technology

Use:

iTAg reagents allow for measurement against one specific peptide

HHS Contribution:

Discovered a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1.

Features:

Suitable for basic and clinical research in a number of applications including drug / vaccine development.

Inventors:

S. Rosenberg, Y. Kawakami

HHS Institute/Agency:

NCI

Licensee:

Beckman Coulter, Inc.

Market Launch:

2005

Back to Table of Contents

2001

Product Name:

iTag™ MHC Tetramers

Use:

Used for the ex vivo quantification of cellular immune response

HHS Contribution:

Sequenced various melanoma peptides

Features:

MHC Tetramer technology has been used to accurately monitor CD8+ T cell responses (viruses, parasitic infections, cancers)

Inventors:

Y. Kawakami, S. Rosenberg

HHS Institute/Agency:

NCI

Licensee:

Beckman Coulter, Inc.

Market Launch:

2001

Back to Table of Contents

2002

Product Name:

K1 antibodies

Use:

Used as a research reagent to enhance the understanding of certain cancers, such as, ovarian, esophageal and cervical carcinomas

HHS Contribution:

Developed monoclonal antibody useful for the diagnosis of cancer

Features:

Can be a diagnostic for the detection of mesothelin positive tumors

Inventors:

M. Willingham, K. Chang, I. Pastan

HHS Institute/Agency:

NCI

Licensee:

Zymed Laboratories, Inc.

Market Launch:

2002

Back to Table of Contents

2004

Product Name:

Kepivance®

Use:

Treatment of severe mouth sores that afflict hematologic cancer patients who receive myelotoxic therapy

HHS Contribution:

Characterized the effects of the chemical palifermin which is a human keratinocyte growth factor (KGF)

Features:

Improves the most debilitating side effect cited for blood cancer therapy

Inventors:

J. Rubin

HHS Institute/Agency:

NCI

Licensee:

Amgen, Inc.

Market Launch:

2004

Back to Table of Contents

2001

Product Name:

Keratinocyte Growth Factor & KGF Antibodies

Use:

Identifies keratinocyte of growth factors, i.e. embryonic development, cell growth, morphogenesis, tumor growth,and invasion

HHS Contribution:

Discovered recombinant DNA technology to produce the human keratinocyte growth factor (KGF) pure proteins

Features:

the gene is connected with morphogenesis of epithelium and early lung organogenesis

Inventors:

J. Rubin

HHS Institute/Agency:

NCI

Licensee:

PeproTech, Inc.

Market Launch:

2001

Back to Table of Contents

1998

Product Name:

LambdaSelect-cII™ Mutation Assay Kit

Use:

Detect in vivo mutations of E. coli phage lambda 1

HHS Contribution:

A novel assay for the detection of mutations in the lambda transgenes

Features:

the number of plaques that need to be screened is reduced

Inventors:

J L Jakubczak, G Merlino, J E French, W J Muller, B Paul, S Adhya, and S Garges

HHS Institute/Agency:

NCI

Licensee:

Stratagene California

Market Launch:

1998

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1997

Product Name:

Long Terminal Repeat Vector

Use:

Uses LTR vectors to screen for a protein of interest.

HHS Contribution:

Describes retrovirus LTR vectors and model sytems involving LTR vectors derived from Maloney sarcoma virus

Features:

Provides access to powerful functional screening capabilities of retroviral technology

Inventors:

D. Blair, M Oskarsson, W. Mcclements, G. Vande Woude

HHS Institute/Agency:

NCI

Licensee:

Stratagene California

Market Launch:

1997

Back to Table of Contents

1999

Product Name:

LTR-Vectors

Use:

Used to make retroviral vectors for development of gene therapy products

HHS Contribution:

Developed LTR sequences

Features:

Provides access to powerful functional screening capabilities of retroviral technology

Inventors:

G. Vande Woude, D. Blair, W. Mcclements, M. Oskarsson

HHS Institute/Agency:

NCI

Licensee:

Novartis Pharma, Genetic Therapy, Inc.

Market Launch:

1999

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1999

Product Name:

LYMErix™

Use:

A noninfectious recombinant vaccine for Lyme's disease

HHS Contribution:

Generated the expression vector pAS1 used for large scale recombinant protein production

Features:

The first vaccine for the prevention of Lyme's disease

Inventors:

M. Rosenberg

HHS Institute/Agency:

NCI

Licensee:

GlaxoSmithKline

Market Launch:

1999

Back to Table of Contents

1997

Product Name:

Macrophage Stimulating Protein

Use:

Activates macrophages to react in the immune system

HHS Contribution:

Discovered a method to purify macrophage stimulating proteins and found that it can be used as a pathogen against infection.

Features:

Significantly impacts the role of macrophages to immune responses

Inventors:

E. Appella, T. Yoshimura, A. Skeel, E. Leonard

HHS Institute/Agency:

NCI

Licensee:

Research and Diagnostic Systems, Inc.

Market Launch:

1997

Back to Table of Contents

2004

Product Name:

MART-1 Antibody

Use:

Diagnostic assay for metastatic melanoma

HHS Contribution:

Identified the immunodominant peptides of the MART-1 human melanoma antigen.

Features:

Can be used in Flow Cytometry, Immunoprecipitation, Western Blot, and Immunohistochemistry.

Inventors:

Y. Kawakami and P. Robbins

HHS Institute/Agency:

NCI

Licensee:

Cell Marque Corporation

Market Launch:

2004

Back to Table of Contents

1993

Product Name:

Matrigel®

Use:

Substrate for culturing cells

HHS Contribution:

Reconstituted basement membrane complex with biological activity

Features:

Allows studying natural cellular behaviors otherwise not observed in the lab

Inventors:

H. Kleinman and G. Martin

HHS Institute/Agency:

NIDCR

Licensee:

Becton Dickinson

Market Launch:

1993

Back to Table of Contents

1997

Product Name:

Melanoma-associated antigen recognized by T cells (MART-1) Antibodies

Use:

This antibody is very useful in establishing the diagnosis of metastatic melanomas

HHS Contribution:

Provided a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1

Features:

Anti-MART-1 is a mouse monoclonal antibody from tissue culture supernatant diluted in phosphate buffered saline, pH 7.4 etc.

Inventors:

Y. Kawakami

HHS Institute/Agency:

NCI

Licensee:

Signet Laboratories, Inc.

Market Launch:

1997

Back to Table of Contents

2003

Product Name:

Melanoma-associated antigen recognized by T cells (MART-1) Melan A

Use:

Labels melanomas and tumors showing melanocytic differentiation

HHS Contribution:

Provided a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1

Features:

Useful addition to melanoma panels which are specific to melanocytic lesions

Inventors:

Y. Kawakami

HHS Institute/Agency:

NCI

Licensee:

Biocare Medical, LLC

Market Launch:

2003

Back to Table of Contents

2005

Product Name:

Mesothelin (K1)

Use:

Used as a therapeutic for mesotheliomas and pancreatic and ovarian tumors

HHS Contribution:

Generated an anti-mesothelin antibody of human origin

Features:

Can be a diagnostic for the detection of mesothelin positive tumors

Inventors:

D. Dimitrov

HHS Institute/Agency:

NCI

Licensee:

Santa Cruz Biotechnology, Inc.

Market Launch:

2005

Back to Table of Contents

1997

Product Name:

Micro HTLV-1/2

Use:

Uses multiple antigens to detect HTLV-1 and HLTV-2

HHS Contribution:

Discovered recombinant HIV envelope proteins to be used in detection assays

Features:

Valuable tool to help detect HTLV

Inventors:

T. Papas

HHS Institute/Agency:

NCI

Licensee:

Abbott Laboratories, Inc.

Market Launch:

1997

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1998

Product Name:

Microsomes, S9 Fractions and Cytosol

Use:

Used for Cytochrome p450 inhibition and phenotyping

HHS Contribution:

Found that MAb 49-10-20 is inhibits and binds to 2B6

Features:

Can choose the liver microsomes and liver S9 fractions from a variety of p450s

Inventors:

H. Gelboin

HHS Institute/Agency:

NCI

Licensee:

Invitrogen Corporation

Market Launch:

1998

Back to Table of Contents

1997

Product Name:

Monoclonal Antibodies to HIV-1

Use:

Identify and trace specific cells or molecules in an organism

HHS Contribution:

Developed monoclonal antibodies for binding HTLV-III proteins and cell lines for their production

Features:

Helps study HIV antigen tissue sections.

Inventors:

M. Sargnadharan, R. Gallo, F. Veronese

HHS Institute/Agency:

NCI

Licensee:

Intracel Corporation

Market Launch:

1997

Back to Table of Contents

1993

Product Name:

Monoclonal antibody

Use:

Markers used for identifying breast cancer cells

HHS Contribution:

Process for Producing Monoclonal Antibodies Reactive with Human Breast Cancer

Features:

Effective in immunofluorescence and immunohistochemistry

Inventors:

J. Schlom, D. Colcher, M. Nuti, P. Hand, F. Austin

HHS Institute/Agency:

NCI

Licensee:

Signet Laboratories, Inc.

Market Launch:

1993

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1995

Product Name:

Monoclonal antibody J52 and C3

Use:

Identify and trace specific cells or molecules in an organism

HHS Contribution:

Developed Monoclonal Antibodies to Cytosolic Thyroid Binding Protein

Features:

Successfully used in Western blot, immunocytochemistry, immunoprecipitation and gel shift procedures.

Inventors:

S. Cheng

HHS Institute/Agency:

NCI

Licensee:

Affinity BioReagents, Inc.

Market Launch:

1995

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1996

Product Name:

Monoclonal Antibody to human CD82

Use:

Identify and trace specific cells or molecules in an organism

HHS Contribution:

Developed monoclonal antibody to human CD82 produced by Clone 50F11

Features:

Plays a role in signal transduction and adhesion

Inventors:

J. Shaw

HHS Institute/Agency:

NCI

Licensee:

BD Biosciences - BD PharMingen

Market Launch:

1996

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1997

Product Name:

Monocyte chemotactic protein-1 Antibodies

Use:

Antibody reacts with mouse/rat/human Monocyte chemotactic protein-1 and is used to detect Monocyte chemotactic protein-1

HHS Contribution:

Discovered that MCP-1 is secreted by PHA-stimulated mononuclear proteins and attracts monocytes

Features:

May be use as a neutralizing antibody

Inventors:

T. Yoshimura

HHS Institute/Agency:

NCI

Licensee:

BD Biosciences - BD PharMingen

Market Launch:

1997

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1998

Product Name:

Mouse anti-14-3-3 epsilon

Use:

Anti-14-3-3 ε recognizes the expressed product of the YWHAE gene, also known as Ywhae.

HHS Contribution:

Discovered an enhanced method of killing tumor cells with human effector cells, such as lymphocytes.

Features:

Enhances the kinase activity of the Raf proto-oncogene and Ras resulting in a kinase signaling pathway

Inventors:

J. Ortaldo

HHS Institute/Agency:

NCI

Licensee:

BD Biosciences - BD PharMingen

Market Launch:

1998

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1996

Product Name:

Mouse Mammary Tumor Virus-bla HeLa Cell Line

Use:

Allows for the analysis of endogenous glucocorticoid receptor signaling

HHS Contribution:

Describes retrovirus Long Termical Repeat vectors and model systems involving LTR vectors derived from the Moloney sarcoma virus

Features:

Has been thoroughly tested for assay performance under different circumstances

Inventors:

D. Blair, M Oskarsson, W. Mcclements, G. Vande Woude

HHS Institute/Agency:

NCI

Licensee:

Invitrogen Corporation

Market Launch:

1996

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1998

Product Name:

Murine D551 antibody

Use:

Identify PLK enzymes in vitro

HHS Contribution:

Developed mu-1883 PLK-peptide

Features:

Specific for mouse PLK identification

Inventors:

D. Ferris

HHS Institute/Agency:

NCI

Licensee:

Upstate Biotechnology, Incorporated

Market Launch:

1998

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1997

Product Name:

Murine Stem Cell Virus Retroviral Expression System

Use:

Contains 3 vectors: pMSCVneo, pMSCVhyg, and pMSCVpuro that enhances research to be done with hard-to-transduce cell lines

HHS Contribution:

Describes retrovirus Long Terminal Peteat vectors and model systems involving LTR vectors derived from the Moloney sarcoma virus

Features:

Changes in the Long Terminal Repeat enhance transcriptional activation and prevent transcriptional suppression in ES and EC cells.

Inventors:

D. Blair, M Oskarsson, W. Mcclements, G. Vande Woude

HHS Institute/Agency:

NCI

Licensee:

Clontech Laboratories, Inc

Market Launch:

1997

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1996

Product Name:

MutaPlax cII-Select Kit

Use:

Measures mutation frequencies of lambda-based in vivo mutagenesis systems using a new positive selection method.

HHS Contribution:

A novel assay for the detection of mutations in the lambda transgene

Features:

Includes MutaPlax™ lambda packaging extracts from NM759 and an extract from strain BHB2688.

Inventors:

S. Garges, S. Adhya, J. Jakubczak, G. Merlino

HHS Institute/Agency:

NCI

Licensee:

Epicentre Technologies Corporation

Market Launch:

1996

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1998

Product Name:

NeoTect®

Use:

Serves as an imaging agent for radiation scans of lung lesions in cancer patients and patients at high-risk for cancer

HHS Contribution:

Chemical procedure for creating the complex, custom-designed peptides and peptide-based reagents

Features:

Offers a less expensive and virtually painless method for determining the malignancy of lung masses

Inventors:

F. Robey

HHS Institute/Agency:

NIDCR

Licensee:

Berlex Laboratories, Inc.

Market Launch:

1998

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1994

Product Name:

NeuTrexin® (Trimetrexate)

Use:

Treatment for infections due to toxoplasma gondii and pneumocystis carinii in immunocompromised patients, including patients with AIDS

HHS Contribution:

Active compound Trimetrexate used as antiparasitic agent in AIDs treatment

Features:

Available as a sterile lyophilized powder

Inventors:

C. Allegra, B. Chabner, J. Drake

HHS Institute/Agency:

NCI

Licensee:

MedImmune Oncology

Market Launch:

1994

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1994

Product Name:

Nitric Oxide Complexes with Polyamines

Use:

Used for the treatment of cardiovascular disorders

HHS Contribution:

Developed novel complexes of Nitric Oxide with Polyamines

Features:

Compounds release nitric oxide (endothelium-derived relaxing factor) under physiological conditions in a sustained and controllable fashion

Inventors:

L. Keefer, J. Harbie

HHS Institute/Agency:

NCI

Licensee:

Dojindo Laboratories

Market Launch:

1994

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2007

Product Name:

Nitric oxide donor {Glycosylated Diazen-Pyrrolidin-1,2-diolates}

Use:

Research tool/reagent for nonhuman investigations

HHS Contribution:

Production of nitric oxide donor, anti-proliferative

Features:

Sigma contains a great variety of NO donors for study

Inventors:

J. Saavedra, A. Srinivasan, L. Keefer

HHS Institute/Agency:

NCI

Licensee:

Sigma Chemical Corporation

Market Launch:

2007

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2005

Product Name:

O6-Benzylguanine

Use:

Employed in various DNA repair mechanism studies

HHS Contribution:

Developed O6-substituted Guanine compounds and methods for depleting O6-Alkylguanine-DNA Alkyltransferase levels

Features:

Involved in the inhibition of AGT-mediated DNA repair

Inventors:

R. Moschel

HHS Institute/Agency:

NCI

Licensee:

Sigma Chemical Corporation

Market Launch:

2005

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2003

Product Name:

Ocuvite® PreserVision

Use:

Nutritional supplement to treat macular degeneration

HHS Contribution:

Unique formulation of nutritional supplement

Features:

First NIH licensed technology in an FDA approved product to be sold over the counter

Inventors:

F. Ferris

HHS Institute/Agency:

NEI

Licensee:

Bausch and Lomb

Market Launch:

2003

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1994

Product Name:

OncoScint Mab

Use:

Serves as a antibody based radiolabeling agent that detects colorectal and ovarian cancer

HHS Contribution:

Produced the antibodies that are reactive with human breast cancer

Features:

Offers a less expensive alternative to PET scans and more widely available

Inventors:

J. Schlom, C. Austin, D. Colcher, P. Hand, M. Nuti

HHS Institute/Agency:

NCI

Licensee:

Cytogen Corporation

Market Launch:

1994

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1996

Product Name:

P450 BACULOSOMES® Reagents

Use:

Used for Cytochrome p450 inhibition and phenotyping

HHS Contribution:

Isolated cDNAs of many human cytochrome p450s and discovered it's expression location among other things

Features:

Infected with recombinant baculovirus containing a cDNA insert for a human P450 to prevent metabolism of other p450s

Inventors:

F. Gonzales, H. Gelboin

HHS Institute/Agency:

NCI

Licensee:

PanVera LLC

Market Launch:

1996

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1999

Product Name:

Parvovirus B19 Immunoassay

Use:

Detection of B19 virus IgM antibodies in human serum and plasma

HHS Contribution:

Recombinant capsid proteins and antibodies against them.

Features:

First diagnostic test for parvovirus B19 infection approved by the FDA

Inventors:

N. Young

HHS Institute/Agency:

NHLBI

Licensee:

University of Leiden (Sub-licensed: Biotrin International)

Market Launch:

1999

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1998

Product Name:

PathVysion® HER-2 DNA Probe Kit

Use:

Prognosis of breast cancer (in conjunction with other clinical data)

HHS Contribution:

Connection of HER2 gene with breast cancer.

Features:

First NIH licensed technology in an FDA approved product to be used in personalized medicine

Inventors:

C. King

HHS Institute/Agency:

NCI

Licensee:

Abbott Molecular Inc.

Market Launch:

1998

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1998

Product Name:

Pathway® Her-2/neu (4B5)

Use:

Assessment of breast cancer patients for whom Herceptin� treatment is considered.

HHS Contribution:

Connection of HER2 gene with breast cancer.

Features:

Second NIH licensed technology in an FDA approved product to be used in personalized medicine

Inventors:

C. King

HHS Institute/Agency:

NCI

Licensee:

Ventana Medical Systems, Inc.

Market Launch:

1998

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1993

Product Name:

pBH10 HIV Clone

Use:

HIV research tool

HHS Contribution:

Developed this HIV-1 genomic clone

Features:

Not infectious in present form

Inventors:

R. Gallo

HHS Institute/Agency:

NCI

Licensee:

Aros Biotech AB

Market Launch:

1993

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2007

Product Name:

PDGFR-α (αR1): sc-32287 (antibody)

Use:

Recommended for detection of PDGFR-α of human origin by IF and FCM

HHS Contribution:

Method for making monoclonal antibodies to alpha Platelet-Derived Growth Factor Receptor (PDGFR)

Features:

Useful for studying relations with chronicmyelomonocyticleukemia

Inventors:

T. Matsui, S. Aaronson, J. Pierce

HHS Institute/Agency:

NCI

Licensee:

Santa Cruz Biotechnology, Inc.

Market Launch:

2007

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2004

Product Name:

Phosphotyrosine mimicking amino acid

Use:

Used as a building block for the synthesis of cell-permeable protein tyrosine phospatase (PTP) inhibitors

HHS Contribution:

Developed O-Malonyl Tyrosyl – Containing SH2 Domain Inihbitors

Features:

Inhibited PTP 1B 20 times more potently than the corresponding phosphotyrosine containing peptide

Inventors:

T. Burke, M. Akamatsu, H. Kole, P. Roller, B. Ye

HHS Institute/Agency:

NCI

Licensee:

Bachem Holding AG

Market Launch:

2004

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1997

Product Name:

PixCell

Use:

Laser Capture Microdissection (LCM) is used for microdissection of single cells or small number of cells

HHS Contribution:

Laser Capture Microdissection (LCM) technique

Features:

Ensures biological molecules like RNA and DNA remain undamaged in the micro-dissection process

Inventors:

L. Liotta and R. Bonner

HHS Institute/Agency:

NCI

Licensee:

Arcturus Engineering, Inc.

Market Launch:

1997

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1996

Product Name:

Platelet derived growth factor HU CD140A MAb

Use:

Reacts with platelet derived growth factor (PDGF) receptor α

HHS Contribution:

Methods to determine the growth of neoplasia using a monoclonal antibody against platelet derived growth factor receptor

Features:

This antibody is routinely tested by flow cytometric analysis.

Inventors:

W. Larochelle, S. Aaronson

HHS Institute/Agency:

NCI

Licensee:

BD Biosciences - BD PharMingen

Market Launch:

1996

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1997

Product Name:

Polyclonal Antibody to HIV-1 Rabbit anti Protease

Use:

Detects mature and precursor proteases

HHS Contribution:

Identified and sequenced the HIV protease necessary for the natural synthesis of HIV

Features:

Binds to recombinant protease (HIV-1)

Inventors:

S. Oroszlan,T. Copeland

HHS Institute/Agency:

NCI

Licensee:

Intracel Corporation

Market Launch:

1997

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2000

Product Name:

PPAR alpha-deficient mouse

Use:

Mouse model used to study biochemical mechanism involved in cholesterol lowering drugs.

HHS Contribution:

Created mouse with PPAR gene knocked out.

Features:

The colony is maintained by incrossing homozygous mice.

Inventors:

F. Gonzales

HHS Institute/Agency:

NCI

Licensee:

Taconic Farm, Inc.

Market Launch:

2000

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2006

Product Name:

Prezista®

Use:

Treatment of patients with HIV-1 strains resistant to more than one protease inhibitor

HHS Contribution:

Robust HIV protease inhibitor

Features:

Second-generation protease inhibitor that overcomes resistance to older agents in this class

Inventors:

J. Erickson

HHS Institute/Agency:

NCI

Licensee:

Tibotec Pharmaceuticals, Ltd.

Market Launch:

2006

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2001

Product Name:

Prolactin Receptor Ab-1 and Hybridoma

Use:

Detects and binds to prolactin receptors

HHS Contribution:

Developed the B6.2 secreting antibody to the Prolactin Receptor

Features:

Involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction.

Inventors:

F. Austin, P. Hand, M. Nuti, D. Cocher, J. Schlom

HHS Institute/Agency:

NCI

Licensee:

NeoMarkers, Inc.

Market Launch:

2001

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1997

Product Name:

ProNectin®

Use:

Used to coat a wide variety of cell culture containers and materials due to its unique ability to promote cell attachment

HHS Contribution:

Genetically engineered protein polymers for use as research reagents

Features:

Provides consistent performance and stability without any animal-derived contaminants

Inventors:

Y. Yamada

HHS Institute/Agency:

NIDCR

Licensee:

Sanyo Chemical Industries, Ltd.

Market Launch:

1997

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2000

Product Name:

Pteridine Oligonucleotides

Use:

Due to exquisite sensitivity to changes in the environment, they can be used for the study of DNA interactions.

HHS Contribution:

Provided novel pteridine nucleotides which may be used in the chemical synthesis of fluorescent oligonucleotides

Features:

Very high quantum yield. Perfect for diagnostic applications

Inventors:

M. Hawkins, W. Pfleiderer, M. Davis, F. Balis

HHS Institute/Agency:

NCI

Licensee:

TriLink BioTechnologies, Inc.

Market Launch:

2000

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2001

Product Name:

QualiCode™ HIV-1/2

Use:

Screens for the presence of antibodies to HIV-1 and HIV-2.

HHS Contribution:

Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and linked the HIV virus to AIDS

Features:

Often used as a confirmatory test as other HIV tests are more likely to give false negatives.

Inventors:

R. Gallo, L. Montagnier, and R. Crowl

HHS Institute/Agency:

NCI

Licensee:

OraSure Technologies, Inc.

Market Launch:

2001

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1998

Product Name:

QualiCode™ HIV - 1/2 Western Blot Kit

Use:

Screens for the presence of antibodies to HIV-1 and HIV-2.

HHS Contribution:

Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and consequently, linked the HIV virus to AIDS

Features:

Often used as a confirmatory test as other HIV tests are more likely to give false negatives.

Inventors:

R. Gallo, L. Montagnier, and R. Crowl

HHS Institute/Agency:

NCI

Licensee:

Immunetics, Inc.

Market Launch:

1998

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2002

Product Name:

Quantikine®

Use:

Designed for the quantitative determination of activated human TGF-b1 concentrations in cell culture supernatant, serum, plasma, and urine

HHS Contribution:

Immunoassay for detection of TGF or an EGF or both.

Features:

A useful kit for the quantitative determination of TGF-beta 1

Inventors:

M. Sporn

HHS Institute/Agency:

NCI

Licensee:

R&D Systems, Inc.

Market Launch:

2002

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1993

Product Name:

Ras p21 ELISA

Use:

Use for the quantitation of circulating ras p21 in human serum and plasma

HHS Contribution:

Obtained five separate monoclonal antibodies that immunoprecipitate (raf)-1 oncoprotein

Features:

Uses a mouse monoclonal Capture Antibody and a biotinylated mouse monoclonal antibody as detector.

Inventors:

U. Rapp

HHS Institute/Agency:

NCI

Licensee:

Oncogene Sciences, Inc.

Market Launch:

1993

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1995

Product Name:

Recombinant HIV-1 protease in bacteria

Use:

Used for designing HIV protease inhibitors, which serves as an important component of combination therapies for HIV

HHS Contribution:

Discovered human immunodeficiency virus specific proteolytic enzyme and developed method for synthesis and renaturation

Features:

Can possibly be used in the treatment of patients with AIDS

Inventors:

S. Oroszlan, T. Copeland

HHS Institute/Agency:

NCI

Licensee:

Veritas, Inc.

Market Launch:

1995

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1997

Product Name:

Recombinant HTLV-1 p21

Use:

Used for ELISA and western blot studies.

HHS Contribution:

Antigenic proteins may be expressed in bacteria using vectors and the proteins are useful in identifying antibodies to the organisms from which the DNA fragments were originally obtained.

Features:

Recognized by antibodies in HTLV-1 positive serum in ELISA and Western Blot

Inventors:

T Papas,

HHS Institute/Agency:

NCI

Licensee:

Intracel Corporation

Market Launch:

1997

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1995

Product Name:

Recombinant Human Interleukin-2

Use:

IL2 plays a central role in the expansion and maintenance of regulatory T cells

HHS Contribution:

Created a sandwich method and a kit for assaying interleukin-2 receptor (IL-2R) in a sample.

Features:

Produced in E. Coli cells

Inventors:

R. Yarchoan, W. Leonard, D. Nelson

HHS Institute/Agency:

NCI

Licensee:

R&D Systems, Inc.

Market Launch:

1995

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2002

Product Name:

Recombinant Human sFRP-4

Use:

sFRPs contain cysteine-rich domain Wnt ligands in Frizzleds that provides a novel, secreted protein that contains a region homogulous to ligand binding domain of a cytokine receptor.

HHS Contribution:

This protein, called Frizzled-related protein (FRP), antagonizes the signaling of the Wnt family of cytokines.

Features:

This protein shows complex functions with respect to cell survival

Inventors:

J. Rubin, S Aaronson

HHS Institute/Agency:

NCI

Licensee:

Techne Corporation

Market Launch:

2002

Back to Table of Contents

1996

Product Name:

Recombinant Pseudomonas Exotoxins

Use:

Used to target the Lewis-Y antigen for therapeutic and diagnostic purposes

HHS Contribution:

Developed the recombinant pseudomonas exotoxin

Features:

The first active immunotoxin with low side effects

Inventors:

I. Pastan, D. Fitzgerald

HHS Institute/Agency:

NCI

Licensee:

Bristol-Myers Squibb Company

Market Launch:

1996

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2006

Product Name:

Recombitek® C4

Use:

Vaccine for dogs against distemper, parvovirus, hepatitis, respiratory disease and parainfluenza virus.

HHS Contribution:

Canarypox-based vector that can enter but not replicate in mammals

Features:

First and only such vaccine in the U.S. that uses canarypox-vectored technology

Inventors:

B. Moss

HHS Institute/Agency:

NIAID

Licensee:

Merial Limited

Market Launch:

2006

Back to Table of Contents

2006

Product Name:

Recombitek® Canine Corona - MLV

Use:

Vaccine for dogs against prevention of diesease due to canine coronavirus

HHS Contribution:

Canarypox-based vector that can enter but not replicate in mammals

Features:

First and only canine coronavirus vaccine in the U.S. that uses canarypox-vectored technology

Inventors:

B. Moss

HHS Institute/Agency:

NIAID

Licensee:

Merial Limited

Market Launch:

2006

Back to Table of Contents

2006

Product Name:

Recombitek® Equine Influenza

Use:

Vaccine for horses against equine influenza virus.

HHS Contribution:

Canarypox-based vector that can enter but not replicate in mammals

Features:

First and only equine influenza virus vaccine in the U.S. that uses canarypox-vectored technology

Inventors:

B. Moss

HHS Institute/Agency:

NIAID

Licensee:

Merial Limited

Market Launch:

2006

Back to Table of Contents

2006

Product Name:

Recombitek® West Nile Virus

Use:

Vaccine for horses as an aid in the prevention of viremia due to West Nile Virus

HHS Contribution:

Canarypox-based vector that can enter but not replicate in mammals

Features:

First and only equine West Nile Virus vaccine in the U.S. that uses canarypox-vectored technology

Inventors:

B. Moss

HHS Institute/Agency:

NIAID

Licensee:

Merial Limited

Market Launch:

2006

Back to Table of Contents

1996

Product Name:

Resiniferatoxin

Use:

Involved in the transmission of pain signals

HHS Contribution:

Labeled resiniferatoxin

Features:

Purity of resiniferatoxin is checked at appropriate intervals using a chromatography method

Inventors:

P. Blumberg,

HHS Institute/Agency:

NCI

Licensee:

DuPont NEN Products

Market Launch:

1996

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2001

Product Name:

Reveal™ G3 Rapid HIV-1 Antibody Test

Use:

Used to detect HIV in serum or plasma

HHS Contribution:

Propagation of HIV in the lab and detection of HIV antibodies.

Features:

Rapid (5 minute) detection of exposure to HIV

Inventors:

R. Gallo, L. Montagnier, and R. Crowl

HHS Institute/Agency:

NCI

Licensee:

MedMira Laboratories, Inc.

Market Launch:

2001

Back to Table of Contents

2000

Product Name:

Rhodamine Green Heptagastrin

Use:

Useful tool for the study of endocytosis

HHS Contribution:

Rhodamine Green-heptagastrin is found to specifically bind to NIH/3T3 cells transfected with human gastrin/CCKB receptor cDNA

Features:

Quantitative estimation of binding and determination of Kd

Inventors:

C. Michejda, N. Tarasova

HHS Institute/Agency:

NCI

Licensee:

Boston Biologicals Inc.

Market Launch:

2000

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2005

Product Name:

SiHa Cell Line - Negative Control

Use:

Detects HPV DNA in human cervical samples

HHS Contribution:

Developed the SiHa and H9 cell lines

Features:

Contains a mix of infected and non-infected cells for research

Inventors:

Yohei Ito

HHS Institute/Agency:

NCI

Licensee:

BBI-Biotech Research Laboratories, Inc.

Market Launch:

2005

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1997

Product Name:

Sporanox® Oral Solution

Use:

Treatment of painful and debilitating fungal infections of the esophagus and mouth, commonly called thrush.

HHS Contribution:

Solubilization of the compound to make it easier for the body to absorb the drug

Features:

First use of itraconazole in a soluble compound for the treatment of oral thrush

Inventors:

J. Pitha

HHS Institute/Agency:

NIA

Licensee:

Janssen Pharmaceutica Products, L.P.

Market Launch:

1997

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1995

Product Name:

Squirrel Free Bird Seed

Use:

Capsaicin-coated birdseed unpalatable to rodents

HHS Contribution:

Treated bird seed preferentially palatable to birds but not palatable to animals having chili pepper sensitive receptors

Features:

Chili peppers are a good source of nutrients for birds as well as vitamin A, vitamin D, and carotene

Inventors:

P. Blumberg

HHS Institute/Agency:

NCI

Licensee:

Dun-Frey Partnership

Market Launch:

1995

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1998

Product Name:

Synagis®

Use:

For prevention/treatment of respiratory syncytial virus (RSV)

HHS Contribution:

Derivation of monoclonal antibodies directed against RSV

Features:

First monoclonal antibody approved by the FDA for an infectious disease.

Inventors:

B. Murphy et al.

HHS Institute/Agency:

NIAID

Licensee:

MedImmune, Inc.

Market Launch:

1998

Back to Table of Contents

1990

Product Name:

Synthetic Oligodeoxyribonucleotides

Use:

Inhibits production of disease-causing proteins

HHS Contribution:

Discovered that Phosphorothioate oligodeoxyribonucleotide analogs can prevent the replication of foreign nucleic acids in the presence of normal living cells.

Features:

Able to inhibit the production of disease-causing proteins

Inventors:

Cy A. Stein, L. Neckers, S. Loke, J Cohen, M Matsukura, K. Shinozuka, G. Zon

HHS Institute/Agency:

NCI

Licensee:

Inex Pharmaceuticals Corp

Market Launch:

1990

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1994

Product Name:

TAG-72/CA72-4 Ab-1 (Clone B72.3)

Use:

Monoclonal Ab used for the detection of the TAG-72 antigen expressed on cancer cells. Useful in distinguishing pulmonary adenocarcinomas from pleural mesotheliomas.

HHS Contribution:

Discovered process for producing monoclonal antibodies that aid in the diagnosis, prognosis and treatment of human breast cancer

Features:

Ab-1 is reportedly useful in distinguishing pulmonary adenocarcinomas (B72.3+) from pleural mesotheliomas (B72.3-)

Inventors:

J. Schlom

HHS Institute/Agency:

NCI

Licensee:

NeoMarkers, Inc.

Market Launch:

1994

Back to Table of Contents

1992

Product Name:

Taxol®

Use:

Treatment of advanced carcinoma of the ovary and as adjuvant treatment of node-positive breast cancer

HHS Contribution:

Improved the method for administering paclitaxel

Features:

Extensive clinical development was done by NCI

Inventors:

G. Vande Woude, W. Wilson, and E. Reed

HHS Institute/Agency:

NCI

Licensee:

Bristol-Myers Squibb Company

Market Launch:

1992

Back to Table of Contents

2004

Product Name:

TAXUS® Express 2

Use:

Paclitaxel-eluting stent used to prevent restenosis after ballon angioplasty of coronary peripheral arteries

HHS Contribution:

Discovered that localized release of paclitaxel prevents artery narrowing from cell growth

Features:

Largest 1st year sales of any FDA approved product in U.S. history

Inventors:

J. Kinsella and S. Sollott

HHS Institute/Agency:

NIA

Licensee:

Angiotech Pharmaceuticals and Boston Scientific

Market Launch:

2004

Back to Table of Contents

1998

Product Name:

Thyrogen®

Use:

Diagnostic tool used in follow-up of patients with specific thyroid cancers

HHS Contribution:

Recombinant form of human thyroid stimulating hormone (TSH)

Features:

Allows treatment of thyroid cancer and obtain reliable diagnostic test results for the recurrence of cancer

Inventors:

F. Wondisford

HHS Institute/Agency:

NIDDK

Licensee:

Genzyme Diagnostics

Market Launch:

1998

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1996

Product Name:

Thyroid hormone Receptor interactor (TRIP13) Monoclonal Antibody (3A5)

Use:

Labels thyrotroph cells of the anterior pituitary and the benign and malignant neoplasms that are derived from these cells.

HHS Contribution:

Screened antibodies reactive to thyroid hormone receptor interactor

Features:

Useful and effective in immunohistochemistry

Inventors:

S. Cheng

HHS Institute/Agency:

NCI

Licensee:

Stressgen Bioreagents Limited Partnership

Market Launch:

1996

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1998

Product Name:

Thyroid Stimulating Hormone (TSH) Polyclonal Antibody

Use:

It stains the thyrotroph cells of the anterior pituitary and the benign and malignant neoplasms that are derived from these cells.

HHS Contribution:

Screened for antibodies that inhibited thyroid hormones to its domain

Features:

Useful and effective in immunohistochemistry

Inventors:

S. Cheng

HHS Institute/Agency:

NCI

Licensee:

Covance Research Products, Inc.

Market Launch:

1998

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1994

Product Name:

TIMP-1 ELISA

Use:

For the quantitation of inhibitor tissure of metalloproteinase-1 in human serum and plasma.

HHS Contribution:

The Metalloproteinase peptide invention is an isolated protein of approximately 23,000 daltons in size that binds to metalloproteinases, and is potentially useful for the detection metalloproteinases.

Features:

Provides with a convenient, accurate, and reproducible method to determine TIMP-1 levels in human serum or plasma

Inventors:

W. Stetler-Stevenson

HHS Institute/Agency:

NCI

Licensee:

Oncogene Sciences, Inc.

Market Launch:

1994

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2005

Product Name:

TIMP-2 ELISA Kits

Use:

The TIMP-2 immunoassay kit utilizes antibodies immobilized on a bead matrix directed against different antigenic sites on the same TIMP-2 molecule.

HHS Contribution:

The Metalloproteinase peptide invention is an isolated protein that binds to metalloproteinases with high affinity and is potentially useful for therapy of pathologic conditions of low production metalloproteinases

Features:

The TIMP-2 immunoassay kit is useful for the determination of TIMP-2 levels in fresh serum and conditioned medium of cells.

Inventors:

W. Stetler-Stevenson

HHS Institute/Agency:

NCI

Licensee:

Fuji Chemical Industries, Ltd.

Market Launch:

2005

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2002

Product Name:

TS 106 antibodies (against Human Thymidylate Synthase)

Use:

Used as a research reagent to enhance the understanding of certain cancers that exhibit elevated expression of thymidylate synthase

HHS Contribution:

Developed monoclonal antibodies for Human Thymidylate Synthase

Features:

A critical target enzyme in cancer chemotherapy

Inventors:

P. Johnston, C. Allegra, B. Chabner, C. Liang

HHS Institute/Agency:

NCI

Licensee:

Zymed Laboratories, Inc.

Market Launch:

2002

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1998

Product Name:

Tumor Associated Antigen Antibodies

Use:

The various antibodies serve as markers for the different kinds of tumors.

HHS Contribution:

Discovered Melanoma antigens and their use in diagnostic and therapeutic methods

Features:

They are excellent for staining of formalin-fixed tissues.

Inventors:

Y. Kawakami

HHS Institute/Agency:

NCI

Licensee:

NeoMarkers, Inc.

Market Launch:

1998

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2001

Product Name:

Twinrix®

Use:

Vaccine against Hepatitis A plus Hepatitis B

HHS Contribution:

Propagation of Hepatitis A virus in cell culture rather than animal hosts

Features:

Simplifies vaccination to Hepatitis

Inventors:

R. Daemer

HHS Institute/Agency:

NIAID

Licensee:

GlaxoSmithKline

Market Launch:

2001

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2001

Product Name:

Various Anti-HMG & Anti-Histone products

Use:

Used as research reagents for studies on the molecular basis of disease

HHS Contribution:

Developed Anti-HMG-17, Anti-HMG-14, Anti-Histone Hlo/H5, Anti-Histone H4 and Anti-HMG-1 Sera

Features:

Evaluated by western blot in RIPA lysates from Hep-G2 cells

Inventors:

M. Bustin

HHS Institute/Agency:

NCI

Licensee:

Upstate Biotechnology, Incorporated

Market Launch:

2001

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2003

Product Name:

Velcade®

Use:

Treatment for multiple myeloma that works by specifically inhibiting an enzyme complex known as the proteosome.

HHS Contribution:

Creation of a freeze-dried powder formulation of boronic acid compounds resulting in longer stable shelf life

Features:

First proteosome inhibitor to be approved by the FDA

Inventors:

S. Gupta

HHS Institute/Agency:

NCI

Licensee:

Millennium Pharmaceuticals, Inc.

Market Launch:

2003

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1991

Product Name:

Videx®

Use:

Treatment of advanced HIV infection in adults or children older than 6 months

HHS Contribution:

Screening of dideoxy inosine for anti-viral activity, preclinical and toxicology research, early clinical development

Features:

Second drug approved for the treatment of HIV infection

Inventors:

H. Mitsuya

HHS Institute/Agency:

NCI

Licensee:

Bristol-Myers Squibb Company

Market Launch:

1991

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1998

Product Name:

Vironostika® HTLV-I/II

Use:

Screens for HTLV-I/II

HHS Contribution:

Developed a cell line that produces monoclonal antibody 2A66 against HTLV-II p19

Features:

Produces same day, reliable results

Inventors:

M. Robert-Gruoff, R. Gallo

HHS Institute/Agency:

NCI

Licensee:

Organon Teknika

Market Launch:

1998

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2001

Product Name:

Vironostika® HTLV-I/II

Use:

Screens for HTLV-I/II

HHS Contribution:

Developed a cell line that produces monoclonal antibody 2A66 against HTLV-II p19

Features:

Produces same day, reliable results

Inventors:

M. Robert-Guroff, R. Gallo

HHS Institute/Agency:

NCI

Licensee:

BioMerieux, Inc.

Market Launch:

2001

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1998

Product Name:

Vitravene™

Use:

Inhibition of CMV eye infections

HHS Contribution:

Discovery that using phosphorothioate oligonucleotides as DNA backbones results in effective anti-viral compounds that are more stable in human cells

Features:

First antisense therapeutic approved for use in humans

Inventors:

J. Cohen

HHS Institute/Agency:

NCI

Licensee:

Isis Pharmaceuticals, Inc.

Market Launch:

1998

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1999

Product Name:

VIVID® CYP1A2 Blue Screening Kit

Use:

Used for the detection of enzyme-drug interactions and CYP450 inhibition

HHS Contribution:

Discovered agents that bind to and inhibit human cytochrome P450 1A2

Features:

Provides an optimized method for studying isozyme-specific CYP450 drug.

Inventors:

H. Gelboin

HHS Institute/Agency:

NCI

Licensee:

Invitrogen Corporation

Market Launch:

1999

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1998

Product Name:

VIVID® CYP3A4 Red Screening Kit

Use:

Enables fast measurements of interactions between drug candidates and cytochrome p450 enzymes.

HHS Contribution:

Described antigen binding polypeptides that specifically bind to many human cytochrome p450s.

Features:

Will allow investigators to rapidly identify interactions of CYP450

Inventors:

H. Gelboin. F. Gonzalez

HHS Institute/Agency:

NCI

Licensee:

Invitrogen Corporation

Market Launch:

1998

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1997

Product Name:

Zenapax®

Use:

Prevention of acute kidney transplant rejection

HHS Contribution:

Use of an antibody to the IL-2 receptor for treating malignancy and autoimmune disorders.

Features:

noninfectious recombinant vaccine

Inventors:

T. Waldman

HHS Institute/Agency:

NCI

Licensee:

Protein Design Laboratory / Hoffman LaRoche

Market Launch:

1997

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2002

Product Name:

Zevalin®

Use:

Treatment of patients with relapsed or refractory B-cell non-Hodgkin's lymphoma.

HHS Contribution:

Method of delivering radioactive compound to the target site while minimizing distribution of the compounds to other organs or tissues

Features:

The first radioimmunotherapy treatment approved for cancer

Inventors:

O. Gansow and M. Brechiel

HHS Institute/Agency:

NCI

Licensee:

Coulter Corporation

Market Launch:

2002

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2012

Product Name:

Zilver® PTX® Drug-Eluting Peripheral Stent

Use:

Used to prevent restenosis after balloon angioplasty of peripheral arteries

HHS Contribution:

Discovered that localized release of paclitaxel prevents artery narrowing from cell growth

Features:

First drug-eluting stent approved in the US to treat peripheral arterial disease

Inventors:

J. Kinsella, S. Sollott

HHS Institute/Agency:

NIA

Licensee:

Angiotech Pharmaceuticals / Cook Medical

Market Launch:

2012

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