Licensing Opportunities

  • Iodonium Analogs as Inhibitors of NADPH Oxidases and other Flavin Dehydrogenases and their Use for Treating Cancer...
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       Ref: E-116-2014 | Updated: Apr 14, 2021 | NCI
  • Inducible Activation Nucleic Acid Hybrid Switch for Conditional Generation of Oligonucleotides
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       Ref: E-065-2019 | Updated: Apr 6, 2021 | NCI
  • Efficacious Fluorinated Cytidine Analog Cancer Therapeutic With Low Toxicity In Animal Studies
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       Ref: E-215-2018 | Updated: Apr 5, 2021 | NCI
  • Single Domain Antibodies (Nanobodies) Targeting SARS-CoV-2 for treating COVID-19
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       Ref: E-253-2020 | Updated: Apr 5, 2021 | NCI
  • EGFRvIII Antibodies for the Treatment of Human Cancer
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       Ref: E-103-2019 | Updated: Mar 29, 2021 | NCI
  • Combined PIKFYVE and p38 MAP Kinase Inhibition for Treating Cancer
    •    Ref: E-138-2019 | Updated: Mar 25, 2021 | NICHD
  • New T-Cell Immunotherapy that Targets Aggressive Epithelial Tumors
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       Ref: E-153-2016 | Updated: Mar 23, 2021 | NCI
  • T-cell Receptors Targeting CD20-Positive Lymphomas and Leukemias
    •    Ref: E-152-2020 | Updated: Mar 23, 2021 | NCI
  • T-Cell Receptors Targeting Epstein Barr Virus Latent Membrane Protein 2 for Treatment of Lymphomas and Epithelial...
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       Ref: E-121-2020 | Updated: Mar 23, 2021 | NCI
  • Tethered Interleukin-15 (IL-15)/IL-21 to Enhance T Cells for Cellular Therapy
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       Ref: E-068-2018 | Updated: Mar 23, 2021 | NCI
  • Monoclonal Antibodies for Detection of Rabies Virus Antigen and Confirmatory Rabies Diagnosis
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       Ref: E-054-2021-0 | Updated: Mar 12, 2021 | CDC
  • A Novel Genetically Encoded Inhibitor of Hippo Signaling Pathway to Study YAP1/TAZ-TEAD Dependent Events in Cancer...
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       Ref: E-108-2019 | Updated: Mar 10, 2021 | NCI
  • Novel Methods for Reducing Inflammation and Treating Diseases such as Parkinson's and Alzheimer's Disease...
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       Ref: E-130-2004-0 | Updated: Mar 10, 2021 | NIEHS
  • Reducing Bloodstream Neutrophils as a Treatment for Lung Infection and Inflammation
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       Ref: E-125-2018-0 | Updated: Mar 8, 2021 | NIEHS
  • Non-invasive diagnostic and prognostic assay for early stage lung cancer
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       Ref: E-121-2013 | Updated: Mar 3, 2021 | NCI
  • Dual Specific Anti-CD22 Anti-CD19 Bicistronic Chimeric Antigen Receptors (CARs)
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       Ref: E-017-2017 | Updated: Mar 1, 2021 |
  • Improved simian HIV (SHIV) prevention in non-human primate models with chemoprophylaxis combination that can be...
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       Ref: E-037-2017-0 | Updated: Mar 1, 2021 | CDC
  • Improved Live-Attenuated Vaccine for Respiratory Syncytial Virus (RSV) Bearing Codon-Pair Deoptimized NS1, NS2, N,...
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       Ref: E-104-2020-0 | Updated: Feb 25, 2021 | NIAID
  • Methods of Producing T-cell Populations Using P38 MAPK Inhibitors
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       Ref: E-002-2018 | Updated: Feb 25, 2021 |
  • 3-o-sulfo-galactosylceramide Analogs as Activators of Type II Natural Killer T (NKT) Cells to Reduce Cancer...
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       Ref: E-100-2018 | Updated: Feb 24, 2021 | NCI
  • Bivalent, Dual Specific Anti-CD22 Anti-CD19 Chimeric Antigen Receptors (CARs)
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       Ref: E-106-2015 | Updated: Feb 24, 2021 | NCI
  • Monoclonal Antibodies Against Coxiella burnetii, the Cause of Q Fever for Diagnostic Development
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       Ref: E-194-2016-0 | Updated: Feb 19, 2021 | CDC
  • Replication-Competent Adenovirus Type 4 SARS-CoV-2 Vaccines and Their Use
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       Ref: E-055-2021-0 | Updated: Feb 19, 2021 | NIAID
  • Stable Human Cell Lines Expressing Flavivirus Virus-Like Particles (VLPs) for Vaccine, Biologics, and Diagnostic...
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       Ref: E-203-2018-0 | Updated: Feb 19, 2021 | CDC
  • Antiviral Compounds with Broad Neutralization Capabilities
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       Ref: E-013-2006-1 | Updated: Feb 17, 2021 | NIAID
  • Epstein-Barr Virus Antibody That Blocks Fusion And Neutralizes Virus Infection of B Cells
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       Ref: E-020-2020-0 | Updated: Feb 16, 2021 | NIAID
  • T Cell Receptors Targeting KRAS Mutants for Cancer Immunotherapy/Adoptive Cell Therapy
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       Ref: E-175-2016 | Updated: Feb 11, 2021 | NCI
  • Monoclonal Antibodies that Bind Zika Virus Envelope Protein for Zika Diagnostics and Research
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       Ref: E-030-2017-0 | Updated: Feb 9, 2021 | CDC
  • Monomeric and Oligomeric Compounds as Contraceptives and Endocrine Therapeutics
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       Ref: E-141-2019 | Updated: Feb 9, 2021 | NICHD
  • Size-dependent brain distribution of macromolecular drug delivery platform
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       Ref: E-078-2020 | Updated: Feb 9, 2021 | FNLCR
  • Zika Virus NS1 Protein Monoclonal Antibodies for Research, Development, and Novel Diagnostics
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       Ref: E-286-2016-0 | Updated: Feb 9, 2021 | CDC
  • Single-Chain Antibodies Directed to Norovirus GI.1 and GII.4 and Their Use
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       Ref: E-136-2013-0 | Updated: Feb 8, 2021 | NIAID
  • A VSV-EBOV-Based Vaccine Against COVID-19
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       Ref: E-258-2020-0 | Updated: Feb 5, 2021 | NIAID
  • 3D Image Rendering Software for Biological Tissues
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       Ref: E-254-2012 | Updated: Jan 26, 2021 | NCI
  • A Mobile Health Platform
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       Ref: E-049-2015 | Updated: Jan 26, 2021 | NIDA
  • A Specialized Tissue Collection Device for the Preservation and Transportation of Needle Biopsies
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       Ref: E-128-2017 | Updated: Jan 26, 2021 | NCI
  • Device for Simulating Explosive Blast and Imaging Biological Specimens
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       Ref: E-068-2012 | Updated: Jan 26, 2021 | NICHD
  • Establishment of Induced Pluripotent Stem Cells (iPSC) from the Thirteen-lined Ground Squirrel
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       Ref: E-059-2017 | Updated: Jan 26, 2021 | NEI
  • Glial Cell Line-Derived Neurotrophic Factor for the Treatment of Neurodegenerative Diseases and Diabetes
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       Ref: E-044-2012 | Updated: Jan 26, 2021 | NIDA
  • Human Research Information System (HuRIS)
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       Ref: E-266-2014 | Updated: Jan 26, 2021 | NIDA
  • Isotropic Generalized Diffusion Tensor MRI
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       Ref: E-093-2017 | Updated: Jan 26, 2021 | NICHD
  • Magnetic Resonance Specimen Evaluation Using Multiple Pulse Field Gradient Sequences
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       Ref: E-276-2008 | Updated: Jan 26, 2021 |
  • Novel Biased Potent Opioid-Like Agonists as Improved Medications to Treat Chronic and Acute Pain
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       Ref: E-017-2018 | Updated: Jan 26, 2021 | NIDA
  • Prefusion-Stabilized Fusion (F) Glycoprotein Vaccine Immunogens For Human Metapneumovirus
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       Ref: E-131-2019-0 | Updated: Jan 26, 2021 | NIAID
  • COMBINATION THERAPIES FOR COVID-19 (SARS-COV-2)
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       Ref: E-006-2021-0 | Updated: Jan 25, 2021 | NIDDK
  • Hybridoma cell lines producing antibodies to RSV NS1
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       Ref: E-167-2018-0 | Updated: Jan 25, 2021 | NIAID
  • High-Throughput COVID-19 Diagnostic Test that Detects Both Viral and Host Nucleic Acid
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       Ref: E-241-2020-0 | Updated: Jan 11, 2021 | NIEHS
  • Stem Cell Factor-responsive FcepsilonRI Bearing Human Mast Cell Line LAD2
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       Ref: E-279-2001-0 | Updated: Jan 7, 2021 | NIAID
  • Antimalarial Inhibitors that Target the Plasmodial Surface Anion Channel (PSAC) Protein and Development of the PSAC...
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       Ref: E-145-2011-0 | Updated: Jan 5, 2021 | NIAID
  • T-cell Receptors (TCRs) Specific for p53 Mutants
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       Ref: E-173-2020 | Updated: Dec 28, 2020 | NCI
  • Small Molecule Inhibitors of Drug Resistant Forms of HIV-1 Integrase
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       Ref: E-093-2013 | Updated: Dec 23, 2020 | NCI
  • A Preclinical Model for Mutant Human EGFR-driven Lung Adenocarcinoma
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       Ref: E-041-2014 | Updated: Dec 15, 2020 | NCI
  • A Preclinical Orthotopic Model for Glioblastoma Multiforme that Represents Key Pathways Aberrant in Human Brain...
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       Ref: E-246-2014 | Updated: Dec 15, 2020 | NCI
  • A Viral Exposure Signature to Define and Detect Early Onset Hepatocellular Carcinoma
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       Ref: E-174-2019 | Updated: Dec 15, 2020 | NCI
  • Parental A2780 Ovarian Cancer Cell Line and Derivative Cisplatin-resistant and Adriamycin-resistant A2780 Cell...
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       Ref: E-018-2020 | Updated: Dec 15, 2020 | NCI
  • Reporter Plasmid to Identify Cancer Stem Cells
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       Ref: E-141-2011 | Updated: Dec 14, 2020 | NCI
  • Leucine Zipper-bearing Kinase (LZK) -Targeting Degraders and Methods of Use
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       Ref: E-163-2020 | Updated: Nov 30, 2020 | NCI
  • Oxynitidine Derivatives Useful as Inhibitors of Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1)...
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       Ref: E-181-2018 | Updated: Nov 30, 2020 | NCI-CCR
  • RNASEH-Assisted Detection Assay for RNA
    •
       Ref: E-193-2020 | Updated: Nov 30, 2020 | NCI, CCR
  • P2Y14 Receptor Antagonists Containing A Biaryl Core
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       Ref: E-028-2018-0 | Updated: Nov 20, 2020 | NIDDK
  • TRIAZOLE DERIVATIVES AS P2Y14 RECEPTOR ANTAGONISTS
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       Ref: E-213-2015-0 | Updated: Nov 20, 2020 | NIDDK
  • Identification of a New Human Monoclonal Antibody that More Potently Prevents Malaria Infection
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       Ref: E-087-2019-0 | Updated: Nov 13, 2020 | NIAID
  • Recombinant Prefusion Measles and Mumps F and F–HN (H) Glycoproteins for Vaccine Development
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       Ref: E-153-2019-0 | Updated: Nov 5, 2020 | NIAID
  • Simian T-Cell Lymphotropic Virus Strain Type 3 (STLV-3) Subtype D Variant, a Highly Divergent STLV-3, for...
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       Ref: E-303-2013-2 | Updated: Oct 30, 2020 | Johns Hopkins University
  • Composite Gels and Methods of their Use in Tissue Repair, Drug Delivery, and as Implants
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       Ref: E-014-2019 | Updated: Oct 27, 2020 | NICHD
  • Dopamine D3 Receptor Agonist Compounds, Methods of Preparation, Intermediates Thereof, and their Methods of Use...
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       Ref: E-077-2019 | Updated: Oct 27, 2020 | NIDA
  • Personalized Body Weight Management System Using Monitoring Devices and Mathematical Models of Metabolism
    •
       Ref: E-063-2012-0 | Updated: Oct 23, 2020 | NIDDK
  • Rescue of AAV Production by shRNA Co-transfection
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       Ref: E-072-2020-0 | Updated: Oct 23, 2020 | NIDCR
  • T-Cell Therapy Against Patient-Specific Cancer Mutations
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       Ref: E-233-2014 | Updated: Oct 19, 2020 | NCI
  • Silica-Coated Nanodiamonds for Imaging and Delivery of Therapeutic Agents
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       Ref: E-175-2012 | Updated: Oct 6, 2020 | NCI
  • Use of the TP5 Peptide for the Treatment of Cancer
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       Ref: E-007-2019 | Updated: Oct 6, 2020 | NCI
  • Structure-Based Design of SARS-CoV-2 Spike Immunogens Stabilized in the RBD-All Down Conformation
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       Ref: E-187-2020-0 | Updated: Oct 5, 2020 | NIAID
  • Assay for Predicting the Time of Onset of Niemann-Pick Disease Type C (NPC)
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       Ref: E-060-2013-0 | Updated: Sep 28, 2020 | NHGRI
  • Codon-Optimized Gene Therapy for Niemann-Pick Disease Type C
    •
       Ref: E-100-2017-0 | Updated: Sep 28, 2020 | NHGRI
  • Gene Therapy for Niemann-Pick Disease Type C
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       Ref: E-185-2014-0 | Updated: Sep 28, 2020 | NHGRI
  • Use of Acetalax for Treatment of Triple Negative Breast Cancer
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       Ref: E-041-2018 | Updated: Sep 25, 2020 | NCI-DTB
  • Platform to Enhance Anti-Tumor Immunity
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       Ref: E-053-2019 | Updated: Sep 22, 2020 | NCI
  • Antibodies and Methods for the Diagnosis and Treatment of Epstein-Barr Virus Infection
    •    Ref: E-001-2017-0 | Updated: Sep 21, 2020 | NIAID
  • Methods for Dagnosing and Treating Mycobacterium tuberculosis (Mtb) Infection through Detection of CD153...
    •
       Ref: E-085-2018-0 | Updated: Sep 21, 2020 | NIAID
  • Use of the Intracellular Signaling Domain of Receptor CD28H as a Component of Chimeric Antigen Receptors to...
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       Ref: E-097-2020-0 | Updated: Sep 21, 2020 | NIAID
  • Angiogenesis-Based Cancer Therapeutic
    •
       Ref: E-230-2011 | Updated: Sep 17, 2020 |
  • A Novel Transgenic Zebrafish Line Reporting Dynamic Epigenetic Changes
    •
       Ref: E-124-2019 | Updated: Sep 16, 2020 | NICHD
  • Detection of Novel Endocrine-Disrupting Chemicals in Water Supplies
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       Ref: E-269-2011 | Updated: Sep 16, 2020 | NCI
  • Fibroblast Growth Factor Receptor 4 (FGFR4) Monoclonal Antibodies and Methods of Their Use
    •    Ref: E-264-2015 | Updated: Sep 16, 2020 | NCI
  • Modulation of Leucine-rich Repeats and Calponin Homology Domain-containing Protein 4 (Lrch4) Activity for...
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       Ref: E-012-2011-0 | Updated: Sep 9, 2020 | NIEHS
  • An In-Vitro Cell System Useful For Identification of RORgamma Antagonists
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       Ref: E-253-2010-0 | Updated: Sep 4, 2020 | NIEHS
  • Cytochromes P450 CYP2J and CYP2C Polyclonal Antibodies and Recombinant Proteins
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       Ref: E-153-2011-0 | Updated: Sep 4, 2020 | NIEHS
  • Development of Reagents to Examine the Expression and Function of CYP2J Subfamily P450s
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       Ref: E-033-2002-0 | Updated: Sep 4, 2020 | NIEHS
  • GLI-Similar 3(GLIS3) Knock Out (KO) Mice as Models to Screen Therapeutics for Diabetes, Polycystic Kidney Disease,...
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       Ref: E-303-2011-0 | Updated: Sep 4, 2020 | NIEHS
  • Hspa2 Knockout Mice for Study of Spermatogenesis and Male Infertility
    •
       Ref: E-052-2011-0 | Updated: Sep 4, 2020 | NIEHS
  • Human Phospho-Serine134 Glucocorticoid Receptor Polyclonal Antibody: Useful for the Characterization of...
    •
       Ref: E-182-2011-0 | Updated: Sep 4, 2020 | NIEHS
  • Isolation of Hybridomas Producing Monoclonal Antibodies (MAbs) Inhibitory to Human CYP2J2
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       Ref: E-337-2003-0 | Updated: Sep 4, 2020 | NIEHS
  • New Mouse Strain with Conditional Deletion of SMAD7: Analysis of Disease Processes Involving Immunological,...
    •
       Ref: E-040-2010-0 | Updated: Sep 4, 2020 | NIEHS
  • RORgamma (RORC) Deficient Mice Which Are Useful for the Study of Lymph Node Organogenesis and Immune Responses
    •
       Ref: E-222-2009-0 | Updated: Sep 4, 2020 | NIEHS
  • Transgenic Hspa2-Cre Mice for Studying Spermatogenesis and Male Infertility
    •
       Ref: E-290-2011-0 | Updated: Sep 4, 2020 | NIEHS
  • Calcium (Ca2+) Flux-Dependent Method to Detect and Isolate Tumor Reactive T Cell Receptors (TCRs)
    •
       Ref: E-168-2018 | Updated: Sep 3, 2020 | NCI
  • Extremely Rapid Method to Isolate Neoantigen Reactive T Cell Receptors (TCRs)
    •
       Ref: E-061-2020 | Updated: Sep 3, 2020 | NCI
  • Margaric Acid Decreases PIEZO2 Mediated Pain
    •
       Ref: E-081-2020 | Updated: Sep 3, 2020 | NCCIH
  • Method of Neoantigen-Reactive T Cell Receptor (TCR) Isolation from Peripheral Blood of Cancer Patients
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       Ref: E-102-2020 | Updated: Sep 3, 2020 | NCI
  • T Cell Receptors (TCRs) Specific for Mutant p53
    •
       Ref: E-135-2019 | Updated: Sep 3, 2020 | NCI

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    Office of Technology Transfer, Office of Intramural Research, National Institutes of Health

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