Licensing Opportunities

  • High-Throughput COVID-19 Diagnostic Test that Detects Both Viral and Host Nucleic Acid
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       Ref: E-241-2020-0 | Updated: Jan 11, 2021 | NIEHS
  • Stem Cell Factor-responsive FcepsilonRI Bearing Human Mast Cell Line LAD2
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       Ref: E-279-2001-0 | Updated: Jan 7, 2021 | NIAID
  • Antimalarial Inhibitors that Target the Plasmodial Surface Anion Channel (PSAC) Protein and Development of the PSAC...
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       Ref: E-145-2011-0 | Updated: Jan 5, 2021 | NIAID
  • T-cell Receptors (TCRs) Specific for p53 Mutants
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       Ref: E-173-2020 | Updated: Dec 28, 2020 | NCI
  • Small Molecule Inhibitors of Drug Resistant Forms of HIV-1 Integrase
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       Ref: E-093-2013 | Updated: Dec 23, 2020 | NCI
  • A Preclinical Model for Mutant Human EGFR-driven Lung Adenocarcinoma
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       Ref: E-041-2014 | Updated: Dec 15, 2020 | NCI
  • A Preclinical Orthotopic Model for Glioblastoma Multiforme that Represents Key Pathways Aberrant in Human Brain...
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       Ref: E-246-2014 | Updated: Dec 15, 2020 | NCI
  • A Viral Exposure Signature to Define and Detect Early Onset Hepatocellular Carcinoma
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       Ref: E-174-2019 | Updated: Dec 15, 2020 | NCI
  • Parental A2780 Ovarian Cancer Cell Line and Derivative Cisplatin-resistant and Adriamycin-resistant A2780 Cell...
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       Ref: E-018-2020 | Updated: Dec 15, 2020 | NCI
  • Reporter Plasmid to Identify Cancer Stem Cells
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       Ref: E-141-2011 | Updated: Dec 14, 2020 | NCI
  • Leucine Zipper-bearing Kinase (LZK) -Targeting Degraders and Methods of Use
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       Ref: E-163-2020 | Updated: Nov 30, 2020 | NCI
  • Oxynitidine Derivatives Useful as Inhibitors of Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1)...
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       Ref: E-181-2018 | Updated: Nov 30, 2020 | NCI-CCR
  • RNASEH-Assisted Detection Assay for RNA
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       Ref: E-193-2020 | Updated: Nov 30, 2020 | NCI, CCR
  • P2Y14 Receptor Antagonists Containing A Biaryl Core
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       Ref: E-028-2018-0 | Updated: Nov 20, 2020 | NIDDK
  • TRIAZOLE DERIVATIVES AS P2Y14 RECEPTOR ANTAGONISTS
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       Ref: E-213-2015-0 | Updated: Nov 20, 2020 | NIDDK
  • Identification of a New Human Monoclonal Antibody that More Potently Prevents Malaria Infection
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       Ref: E-087-2019-0 | Updated: Nov 13, 2020 | NIAID
  • Recombinant Prefusion Measles and Mumps F and F–HN (H) Glycoproteins for Vaccine Development
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       Ref: E-153-2019-0 | Updated: Nov 5, 2020 | NIAID
  • Simian T-Cell Lymphotropic Virus Strain Type 3 (STLV-3) Subtype D Variant, a Highly Divergent STLV-3, for...
    •
       Ref: E-303-2013-2 | Updated: Oct 30, 2020 | Johns Hopkins University
  • Composite Gels and Methods of their Use in Tissue Repair, Drug Delivery, and as Implants
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       Ref: E-014-2019 | Updated: Oct 27, 2020 | NICHD
  • Dopamine D3 Receptor Agonist Compounds, Methods of Preparation, Intermediates Thereof, and their Methods of Use...
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       Ref: E-077-2019 | Updated: Oct 27, 2020 | NIDA
  • Personalized Body Weight Management System Using Monitoring Devices and Mathematical Models of Metabolism
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       Ref: E-063-2012-0 | Updated: Oct 23, 2020 | NIDDK
  • Rescue of AAV Production by shRNA Co-transfection
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       Ref: E-072-2020-0 | Updated: Oct 23, 2020 | NIDCR
  • T-Cell Therapy Against Patient-Specific Cancer Mutations
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       Ref: E-233-2014 | Updated: Oct 19, 2020 | NCI
  • Silica-Coated Nanodiamonds for Imaging and Delivery of Therapeutic Agents
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       Ref: E-175-2012 | Updated: Oct 6, 2020 | NCI
  • Use of the TP5 Peptide for the Treatment of Cancer
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       Ref: E-007-2019 | Updated: Oct 6, 2020 | NCI
  • Structure-Based Design of SARS-CoV-2 Spike Immunogens Stabilized in the RBD-All Down Conformation
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       Ref: E-187-2020-0 | Updated: Oct 5, 2020 | NIAID
  • Assay for Predicting the Time of Onset of Niemann-Pick Disease Type C (NPC)
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       Ref: E-060-2013-0 | Updated: Sep 28, 2020 | NHGRI
  • Codon-Optimized Gene Therapy for Niemann-Pick Disease Type C
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       Ref: E-100-2017-0 | Updated: Sep 28, 2020 | NHGRI
  • Gene Therapy for Niemann-Pick Disease Type C
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       Ref: E-185-2014-0 | Updated: Sep 28, 2020 | NHGRI
  • Use of Acetalax for Treatment of Triple Negative Breast Cancer
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       Ref: E-041-2018 | Updated: Sep 25, 2020 | NCI-DTB
  • Platform to Enhance Anti-Tumor Immunity
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       Ref: E-053-2019 | Updated: Sep 22, 2020 | NCI
  • Antibodies and Methods for the Diagnosis and Treatment of Epstein-Barr Virus Infection
    •    Ref: E-001-2017-0 | Updated: Sep 21, 2020 | NIAID
  • Methods for Dagnosing and Treating Mycobacterium tuberculosis (Mtb) Infection through Detection of CD153...
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       Ref: E-085-2018-0 | Updated: Sep 21, 2020 | NIAID
  • Use of the Intracellular Signaling Domain of Receptor CD28H as a Component of Chimeric Antigen Receptors to...
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       Ref: E-097-2020-0 | Updated: Sep 21, 2020 | NIAID
  • Angiogenesis-Based Cancer Therapeutic
    •
       Ref: E-230-2011 | Updated: Sep 17, 2020 |
  • A Novel Transgenic Zebrafish Line Reporting Dynamic Epigenetic Changes
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       Ref: E-124-2019 | Updated: Sep 16, 2020 | NICHD
  • Detection of Novel Endocrine-Disrupting Chemicals in Water Supplies
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       Ref: E-269-2011 | Updated: Sep 16, 2020 | NCI
  • Fibroblast Growth Factor Receptor 4 (FGFR4) Monoclonal Antibodies and Methods of Their Use
    •    Ref: E-264-2015 | Updated: Sep 16, 2020 | NCI
  • Modulation of Leucine-rich Repeats and Calponin Homology Domain-containing Protein 4 (Lrch4) Activity for...
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       Ref: E-012-2011-0 | Updated: Sep 9, 2020 | NIEHS
  • An In-Vitro Cell System Useful For Identification of RORgamma Antagonists
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       Ref: E-253-2010-0 | Updated: Sep 4, 2020 | NIEHS
  • Cytochromes P450 CYP2J and CYP2C Polyclonal Antibodies and Recombinant Proteins
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       Ref: E-153-2011-0 | Updated: Sep 4, 2020 | NIEHS
  • Development of Reagents to Examine the Expression and Function of CYP2J Subfamily P450s
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       Ref: E-033-2002-0 | Updated: Sep 4, 2020 | NIEHS
  • GLI-Similar 3(GLIS3) Knock Out (KO) Mice as Models to Screen Therapeutics for Diabetes, Polycystic Kidney Disease,...
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       Ref: E-303-2011-0 | Updated: Sep 4, 2020 | NIEHS
  • Hspa2 Knockout Mice for Study of Spermatogenesis and Male Infertility
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       Ref: E-052-2011-0 | Updated: Sep 4, 2020 | NIEHS
  • Human Phospho-Serine134 Glucocorticoid Receptor Polyclonal Antibody: Useful for the Characterization of...
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       Ref: E-182-2011-0 | Updated: Sep 4, 2020 | NIEHS
  • Isolation of Hybridomas Producing Monoclonal Antibodies (MAbs) Inhibitory to Human CYP2J2
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       Ref: E-337-2003-0 | Updated: Sep 4, 2020 | NIEHS
  • New Mouse Strain with Conditional Deletion of SMAD7: Analysis of Disease Processes Involving Immunological,...
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       Ref: E-040-2010-0 | Updated: Sep 4, 2020 | NIEHS
  • RORgamma (RORC) Deficient Mice Which Are Useful for the Study of Lymph Node Organogenesis and Immune Responses
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       Ref: E-222-2009-0 | Updated: Sep 4, 2020 | NIEHS
  • Transgenic Hspa2-Cre Mice for Studying Spermatogenesis and Male Infertility
    •
       Ref: E-290-2011-0 | Updated: Sep 4, 2020 | NIEHS
  • Calcium (Ca2+) Flux-Dependent Method to Detect and Isolate Tumor Reactive T Cell Receptors (TCRs)
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       Ref: E-168-2018 | Updated: Sep 3, 2020 | NCI
  • Extremely Rapid Method to Isolate Neoantigen Reactive T Cell Receptors (TCRs)
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       Ref: E-061-2020 | Updated: Sep 3, 2020 | NCI
  • Margaric Acid Decreases PIEZO2 Mediated Pain
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       Ref: E-081-2020 | Updated: Sep 3, 2020 | NCCIH
  • Method of Neoantigen-Reactive T Cell Receptor (TCR) Isolation from Peripheral Blood of Cancer Patients
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       Ref: E-102-2020 | Updated: Sep 3, 2020 | NCI
  • T Cell Receptors (TCRs) Specific for Mutant p53
    •
       Ref: E-135-2019 | Updated: Sep 3, 2020 | NCI
  • Combination of Near Infrared Photoimmunotherapy Targeting Cancer Cells and Host-Immune Activation
    •
       Ref: E-113-2018 | Updated: Aug 24, 2020 | NCI
  • Denoising of Dynamic Magnetic Resonance Spectroscopic Imaging Using Low Rank Approximations in the Kinetic Domain...
    •
       Ref: E-063-2017 | Updated: Aug 24, 2020 | NCI
  • T-cell Receptors Targeting CD20-Positive Lymphomas and Leukemias
    •    Ref: E-152-2020 | Updated: Aug 19, 2020 | NCI
  • Compounds that Interfere with the Androgen Receptor Complex
    •
       Ref: E-162-2009 | Updated: Aug 17, 2020 | NCI
  • Convolutional Neural Networks for Organ Segmentation
    •
       Ref: E-182-2016 | Updated: Aug 17, 2020 | CC
  • Gene Therapy for Treatment of CRX-Autosomal Dominant Retinopathies
    •
       Ref: E-008-2020 | Updated: Aug 17, 2020 | NEI
  • High Affinity Nanobodies Targeting B7-H3 (CD276) for Treating Solid Tumors
    •
       Ref: E-185-2019 | Updated: Aug 17, 2020 | NCI
  • Humanized Mouse Model to Study Mesothelin (MSLN) -targeted Cancer Therapeutics: Bl6/TPO Mice
    •
       Ref: E-096-2020 | Updated: Aug 17, 2020 | NCI
  • Progressive and Multipath Neural Network for Medical Image Segmentation
    •
       Ref: E-109-2017 | Updated: Aug 17, 2020 | NIHCC
  • Therapeutic Immunotoxins with Increased Half-Life and Anti-Tumor Activity
    •
       Ref: E-179-2019 | Updated: Aug 17, 2020 | NCI
  • Learning to Read Chest X-Rays: Recurrent Neural Cascade Model for Automated Image Annotation
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       Ref: E-045-2016 | Updated: Aug 16, 2020 | NIH-CC
  • A method to label heparan sulfate proteoglycan in the plasma membrane of mammalian cells
    •
       Ref: E-143-2019-0 | Updated: Aug 13, 2020 | NIDDK
  • Cell Line for Production of Recombinant Human Tissue Inhibitor of Metalloproteinase-2
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       Ref: E-216-2017 | Updated: Aug 13, 2020 | NCI
  • Methods and Compositions for Treating Genetically Linked Diseases of the Eye
    •
       Ref: E-284-2012 | Updated: Aug 13, 2020 | NEI
  • Methods of Producing Thymic Emigrants from Induced Pluripotent Stem Cells
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       Ref: E-250-2016 | Updated: Aug 13, 2020 | NCI
  • Mobile Interconnected Evaluation and Learning Software
    •
       Ref: E-224-2017 | Updated: Aug 13, 2020 | NIDA
  • Novel Regulatory B cells for Treatment of Cancer and Autoimmune Disease
    •
       Ref: E-101-2010 | Updated: Aug 13, 2020 | NIA
  • Use of Cucurbitacins and Withanolides for the Treatment of Cancer
    •
       Ref: E-050-2010 | Updated: Aug 13, 2020 | NCI
  • Gene-based Diagnostic Predicts Patient Response to Cancer Immunotherapy
    •
       Ref: E-022-2017 | Updated: Aug 12, 2020 | NCI
  • Lentiviral Vectors with Dual Fluorescence/Luminescence Reporters
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       Ref: E-132-2011 | Updated: Aug 12, 2020 | NCI
  • Diagnostic for Cancer of the Adrenal Glands and Adrenal Cortex
    •
       Ref: E-135-2012 | Updated: Aug 10, 2020 | NCI
  • Monoclonal Antibody Fragments for Targeting Therapeutics to Growth Plate Cartilage
    •
       Ref: E-003-2014 | Updated: Aug 7, 2020 | NICHD
  • Autophagy Modulators For Use in Treating Cancer
    •
       Ref: E-003-2018 | Updated: Aug 6, 2020 | NICHD
  • Self-Assembled Ferritin Nanoparticles Expressing Hemagglutinin as an Influenza Vaccine
    •
       Ref: E-293-2011-0 | Updated: Aug 3, 2020 | NIAID
  • Antisense Oligonucleotides against Cancer Cell Migration and Invasion
    •
       Ref: E-041-2020 | Updated: Jul 21, 2020 | NCI
  • T Cell Receptors Targeting KRAS Mutants for Cancer Immunotherapy/Adoptive Cell Therapy
    •
       Ref: E-175-2016 | Updated: Jul 21, 2020 | NCI
  • Novel One-Well Limiting-Antigen Avidity Enzyme Immunoassay to Detect Recent HIV-1 Infection Using a Multi-subtype...
    •
       Ref: E-522-2013-0 | Updated: Jul 9, 2020 |
  • Aryl Hydantoin Heterocycle Compounds that Target the Androgen Receptor for Prostate Cancer Treatment
    •    Ref: E-169-2018 | Updated: Jul 7, 2020 | NCI
  • Reporter Assay for Detection and Quantitation of Replication-Competent Gammaretrovirus
    •
       Ref: E-125-2020 | Updated: Jul 7, 2020 | NCI
  • A Varicella-Zoster Virus Mutant that is Markedly Impaired for Latent Infection Available for the Development of...
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       Ref: E-029-2007-0 | Updated: Jul 6, 2020 | NIAID
  • Broadly Protective Influenza Vaccine Comprising a Cocktail of Inactivated Avian Influenza Viruses
    •
       Ref: E-033-2018-0 | Updated: Jul 6, 2020 | NIAID
  • Cloned Genome of Infectious Hepatitis C Virus of Genotype 2a and Uses Thereof
    •
       Ref: E-100-1999-0 | Updated: Jul 6, 2020 | NIAID
  • Cloned Genomes Of Infectious Hepatitis C Virus And Uses Thereof
    •
       Ref: E-050-1998-0 | Updated: Jul 6, 2020 | NIAID
  • Diagnostic Reagents And Vaccines For Multiple Genotypes Of Hepatitis C Virus
    •
       Ref: E-120-1993-0 | Updated: Jul 6, 2020 | NIAID
  • Four Chimpanzee Monoclonal Antibodies that Neutralize Hepatitis A Virus
    •
       Ref: E-356-2001-0 | Updated: Jul 6, 2020 | NIAID
  • HCV/BVDV Chimeric Genomes and Uses Thereof
    •
       Ref: E-102-1999-0 | Updated: Jul 6, 2020 | NIAID
  • Infectious cDNA Clone of GB Virus B and Uses Thereof
    •
       Ref: E-173-1999-0 | Updated: Jul 6, 2020 | NIAID
  • Major Neutralization Site of Hepatitis E Virus and Use of this Neutralization Site in Methods of Vaccination
    •
       Ref: E-043-2000-0 | Updated: Jul 6, 2020 | NIAID
  • Monoclonal Antibodies Against Bacillus Anthracis Antigens
    •
       Ref: E-146-2004-0 | Updated: Jul 6, 2020 | NIAID
  • Monoclonal Antibodies Against Orthopoxviruses
    •
       Ref: E-145-2004-3 | Updated: Jul 6, 2020 | NIAID
  • Monoclonal Antibodies Specific for the E2 Glycoprotein of Hepatitis C Virus and Their Use in the Diagnosis,...
    •
       Ref: E-017-2001-0 | Updated: Jul 6, 2020 | NIAID
  • Monoclonal Antibodies That Bind or Neutralize Hepatitis B Virus
    •
       Ref: E-144-2004-0 | Updated: Jul 6, 2020 | NIAID
  • Monoclonal Antibodies that Neutralize Norovirus
    •
       Ref: E-226-2011-0 | Updated: Jul 6, 2020 | NIAID
  • Neutralizing Monoclonal Antibodies to Botulinum Neurotoxin Type A
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       Ref: E-180-2006-0 | Updated: Jul 6, 2020 | NIAID
  • North-2'-Deoxy-Methanocarbathymidines as Antiviral Agents Against Poxviruses
    •
       Ref: E-047-2005-0 | Updated: Jul 6, 2020 | NIAID
  • Polyvalent Influenza Virus-Like Particles (VLPs) and Use as Vaccines
    •
       Ref: E-195-2014-0 | Updated: Jul 6, 2020 | NIAID

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    Office of Technology Transfer, Office of Intramural Research, National Institutes of Health

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