Conditionally Immortalized Cell Line of Metanephric Mesenchyme

An immortalized rat cell line with characteristics of undifferentiated kidney blastemal cells has been established (Kidney Int. 60:2075, 2003). Not only can these cells be maintained in culture, but they retain the capacity to differentiate into epithelial-like cells. This cell line may have utility in studying the molecular mechanisms of mesenchymal-epithelial conversion, kidney development, and kidney tumorigenesis. It may also have future application in the development of renal xenographs or other forms of kidney tissue transplantation.


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Updated: Apr 1, 2005