Technology Bundle ID: TAB-96

Laminin A Peptides

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Licensing Contact:
Co-Inventors: 
Hynda Kleinman (NIDCR)
Therapeutic Area: 
Oncology
Application: 
Research Materials
Institute or Center: 
NIDCR

This invention relates to peptides and derivatives thereof having laminin-like activity, as well as a pharmaceutical composition of the peptide. The peptides claimed include Serine-Isoleucine-Lysine-Valine-Alanine-Valine (SIKVAV). Methods for promoting increased adhesion and migration of epithelial cells is also disclosed. The peptides have wide usage in research, nerve regeneration and cancer treatment. For example, this invention may be useful as an adhesion and regeneration agent for nerve guides and as an adhesion agent for vascular prosthesis.

Applications:
  • adhesion agent
  • cancer therapeutic
  • research reagent
Advantages:
  • key extracellular matrix component
  • widespread biological activity

Patents

EIR Application
PCT Application PCT/US89/004871
Filed on 1989-11-06
US Application 07/530,969
Filed on 1990-05-30
US Application 08/411,067
Filed on 1995-03-27
US Pat 5,211,657

Issued 1993-05-18

Publications

BS Weeks, E Holloway, PE Klotman, SK Akiyama, HW Schnaper, HK Kleinman. 12-O-tetradecanoylphorbol 13-acetate stimulates human T-lymphocyte adherence to the fibronectin RGD domain and the laminin IKVAV domain. Cell Immunol 1994 Jan;153(1):94-104.
JJ Barchi, P Russ, B Johnson, A Otaka, M Nomizu, Y Yamada. Glycosylation of the active sequence Ser-Ile-Lys-Val-Ala-Val from (1 chain of laminin reduces tumor cell attachment activity. Bioorganic Medinal Chem Lett 5:711, 1995.
M Nomizu, BS Weeks, CA Weston, WH Kim, HK Kleinman, Y Yamada. Structure-activity study of a laminin alpha 1 chain active peptide segment Ile-Lys-Val-Ala-Val (IKVAV). FEBS Lett 1995 May 29;365(2-3):227-3.
MC Kibbey, B Johnson, R Petryshyn, M Jucker, HK Kleinman. A 110-kD nuclear shuttling protein, nucleolin, binds to the neurite-promoting IKVAV site of laminin-1. J Neurosci Res 1995 Oct 15;42(3):314-22.
MC Kibbey, ML Corcoran, LM Wahl, HK Kleinman. Laminin SIKVAV peptide-induced angiogenesis in vivo is potentiated by neutrophils. J Cell Physiol 1994 Jul;160(1):185-93.
RS Bresalier, B Schwartz, YS Kim, QY Duh, HK Kleinman, PM Sullam. The laminin alpha 1 chain Ile-Lys-Val-Ala-Val (IKVAV)-containing peptide promotes liver colonization by human colon cancer cells. Cancer Res 1995 Jun 1;55(11):2476-80.

License Status

Available for licensing.

Updated

Oct 1, 1997

Data Source: 
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