Technology Bundle ID: TAB-908

Enzymatically-Active RNA-Dependent RNA Polymerase From a Human Norovirus (Calicivirus)

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Primary Inventors: 
Gael Belliot (NIAID), Kyeong-Ok Chang (NIAID)
Co-Inventors: 
Lisbeth Kim Green (NIAID), Stanislav Sosnovtsev (NIAID)
Therapeutic Area: 
Infectious Disease
Application: 
Research Materials
Institute or Center: 
NIAID

The noroviruses (formerly known as “Norwalk-like viruses”) are associated with gastroenteritis outbreaks, affecting large numbers of individuals each year. Emerging data are supporting their increasing recognition as important agents of diarrhea-related morbidity and mortality. The frequency with which noroviruses are associated with gastroenteritis as “food and water-borne pathogens” has led to the inclusion of caliciviruses as Category B Bioterrorism Agents/Diseases. Because the noroviruses cannot be propagated by any means in the laboratory, an important strategy in their study is to development of molecular biology-based tools and replication systems. This invention reports the isolation of the first recombinant, enzymatically-active proteinase and RNA dependent RNA polymerase (RdRp) complex for a human norovirus. This enzyme should facilitate studies aimed at developing therapeutic drugs for norovirus disease.

Patents

EIR Application

Research Material -- Patent prosecution is not being pursued for these technologies

Research Material -- Patent protection is not being pursued for this technology

Publications

Wei L, et al. Proteinase-polymerase precursor as the active form of feline calicivirus RNA-dependent RNA polymerase.
PMID 11152494

License Status

The materials embodied in this invention are available nonexclusively through a biological materials license.

Updated

Jun 1, 2008

Data Source: 
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