Technology Bundle ID: TAB-860

Brother of the Regulator of Imprinted Sites (BORIS)

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Primary Inventors: 
Victor Lobanenkov (NIAID)
Therapeutic Area: 
Oncology
Application: 
Diagnostics
Institute or Center: 
NIAID

The subject application discloses an isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence encoding a human or a non-human BORIS, or a fragment of either of the foregoing; an isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence that is complementary to a nucleotide sequence encoding a human or a non-human BORIS, or a fragment of either of the following; a vector comprising such an isolated or purified polypeptide molecule consisting essentially of an amino acid sequence encoding a human or a non-human BORIS, or a fragment or either of the foregoing; a cell line that produces a monoclonal antibody that is specific for an aforementioned isolated or purified polypeptide molecule; and the monoclonal antibody produced by the cell line; methods of diagnosing a cancer or a predisposition to a cancer in a male or female mammal; a method of prognosticating a cancer in a mammal; a method of assessing the effectiveness of treatment of a cancer in a mammal; a method of treating a mammal prophylactically or therapeutically for a cancer; and a composition comprising a carrier and an inhibitor of BORIS.

Patents

EIR Application
PCT Application PCT/US2003/05186
Filed on 2003-02-21
US Application 60/358,889
Filed on 2002-02-22
US Pat 7,375,206

Issued 2008-05-20

Updated

Feb 1, 2004

Data Source: 
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