Technology Bundle ID
TAB-843

IL-21 Critically Regulates Immunoglobulin Production

Applications
Research Materials
Linked ID
E-211-2002-0
Lead Inventors
Warren Leonard (NHLBI)
Co-Inventors
Katsutoshi Ozaki (NHLBI)
Rosanne Spolski (NHLBI)
ICs
NHLBI
The invention includes a mouse in which the IL-21 receptor gene is disrupted by homologous recombination, the disruption being sufficient to prevent expression of the IL-21 receptor and thus to inhibit the action of IL-21. The invention also includes a mouse in which both the IL-21 receptor gene and the IL-4 gene are simultaneously disrupted in fashions being sufficient to inhibit the action of IL-21 and the production of IL-4. In a homozygous state, these mutations produce a mouse that has diminished B cell function.

This invention also relates to the use of agents that inhibit the interaction of IL-21 with the IL-21 receptor to modulate an immune response. This invention may be used to alter B cell activity, to treat a subject with Job's disorder, to treat an allergic reaction in a subject, or prevent an allergic reaction in a subject,

Request More Info

Licensing Contact: