Technology Bundle ID: TAB-3383

Floxed Targeted Mouse Strain for Use in Conditional Deletion of the Irf8 Gene

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Primary Inventors: 
Herbert Morse (NIAID)
Application: 
Research Materials
Institute or Center: 
NIAID

IRF8, a member of interferon regulatory factor (IRF) family of transcription factors is a novel intrinsic transcriptional inhibitor of TH17-cell differentiation. TH17-cells are believed to be involved in the pathogenesis of various autoimmune/inflammatory diseases.
These materials could be used to help define patterns of gene expression important for the development and function of cells including possible contributions to understanding: normal immune responses, inflammatory conditions, autoimmunity and anti-viral responses.

Applications:
  • Target identification in B and T cell deficiency, macrophage defects and hematopoiesis
  • A tool for investigating IRF8 mediated issues associated with inflammation and autoimmunity
  • Investigative tool for development of potential therapeutics for lymphoma and Human Chronic Myeloid Leukemia
Advantages:
  • Mice with established germ line transmission for use in conditional deletion of the IRF8 gene in any cellt type

Publications

Updated

Aug 27, 2019

Data Source: 
tts