Technology Bundle ID: TAB-3120

Compositions and Methods for Detecting Loa loa

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Primary Inventors: 
Thomas Nutman (NIAID)
Co-Inventors: 
Papa Drame (NIAID), Sasisekha Bennuru (NIAID)
Institute or Center: 
NIAID

Loa loa is a filarial nematode estimated to infect 3-13 million people in Central and Western Africa. In parts of Africa, mass administration of ivermectin is common for onchocerciasis and lymphatic filariasis control. However, some individuals infected with Loa loa microfilariae in high densities are known to experience post-ivermectin severe adverse events, such as encephalopathy, coma, or even death. Therefore, diagnostic tools that can accurately identify and differentiate Loa loa microfilariae from other filarial infections are needed. Microscopic evaluation of blood samples is the only current diagnostic method used to detect Loa loa microfilaremia in endemic areas, and is impractical for widespread screening. Molecular based assays are useful and are quantitative, but require the use of sophisticated instrumentation.

The inventors analyzed samples from Loa loa infected patients and uninfected controls, and have identified Loa loa microfilaria-specific antigens. The pending application claims a variety of means of detecting these antigens.

Applications:
  • Diagnostics
    Advantages:
    • Highly specific to Loa loa microfilariae
    • Highly sensitive
    • Both diagnostic and quantitative
    • Works with blood, urine, or saliva sample

    Patents

    PCT Application PCT/US16/029673
    Filed on 2016-04-28
    US Application 62/153,654
    Filed on 2015-04-28
    US Pat 10,598,655

    Issued 2020-03-24

    Publications

    Drame PM, et al.
    PMID 26884435

    Updated

    Apr 12, 2017

    Data Source: 
    tts