Technology Bundle ID: TAB-31

Thymosin alpha 1 Promotes Tissue Repair, Angiogenesis and Cell Migration

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Primary Inventors: 
Katherine Malinda (NIDCR)
Co-Inventors: 
Allan Goldstein (EM), Hynda Kleinman (NIDCR)
Development Stage: 
Pre-clinical (in vivo)
Institute or Center: 
NIDCR

These applications describe the use of the compound thymosin alpha 1 as an agent for promoting wound healing. Thymosin alpha 1 is a small, 28 mer, peptide which can be made by chemical synthesis or recombinantly. Studies using a punch model for wounds in rats have shown that providing thymosin alpha1 either intraperitoneally or topically accelerates wound healing. In addition, thymosin alpha 1 has been shown to promote endothelial and keratinoctye cell migration in vivo and to promote angiogenesis in vivo.

Patents

US Application 60/065,032
Filed on 1997-11-10

Publications

This work has been published in J. Immunol. 160(2): 1001-6 (Jan 15, 1998).

Updated

Dec 1, 1998

Data Source: 
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