Technology Bundle ID: TAB-31

Thymosin alpha 1 Promotes Tissue Repair, Angiogenesis and Cell Migration

Request More Info
Licensing Contact:
Primary Inventors: 
Katherine Malinda (NIDCR)
Allan Goldstein (EM), Hynda Kleinman (NIDCR)
Development Stage: 
Pre-clinical (in vivo)
Institute or Center: 

These applications describe the use of the compound thymosin alpha 1 as an agent for promoting wound healing. Thymosin alpha 1 is a small, 28 mer, peptide which can be made by chemical synthesis or recombinantly. Studies using a punch model for wounds in rats have shown that providing thymosin alpha1 either intraperitoneally or topically accelerates wound healing. In addition, thymosin alpha 1 has been shown to promote endothelial and keratinoctye cell migration in vivo and to promote angiogenesis in vivo.


US Application 60/065,032
Filed on 1997-11-10


This work has been published in J. Immunol. 160(2): 1001-6 (Jan 15, 1998).


Dec 1, 1998

Data Source: