Technology Bundle ID: TAB-2669

Recombinant NIE Antigen from Strongyloides stercoralis

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Licensing Contact:
Primary Inventors: 
Thomas Nutman (NIAID)
Co-Inventors: 
Franklin Neva (NIAID), Ravi Varatharajalu (NIAID)
Therapeutic Area: 
Infectious Disease
Application: 
Research Materials
Development Status: 
  • Prototype
  • Pilot
  • Pre-clinical
  • In vitro data available
  • In vivo data available (human)
Institute or Center: 
NIAID

Strongyloides stercoralis is an intestinal nematode endemic that affects an estimated 30 to 100 million people worldwide. Many of these individuals may be asymptomatic for decades. The present invention discloses a NIE recombinant antigen that can be used in improved assays and diagnostics for S. stercoralis infection. The NIE antigen is the only one that is non-cross-reactive with sera from humans with other related filaria infections. The NIE antigen can be utilized as a skin test antigen for immediate hypersensitivity as well as for use in ELISA or other assays.

Applications:
  • Assays and diagnostics for S. stercoralis infection
Advantages:
  • Only non-cross-reactive Strongyloides antigen
  • Use in a variety of formats

Patents

EIR Application

Research Material – Patent protection is not being pursued for this technology.

Publications

Krolewiecki AJ, et al.
PMID 20739501
Ramanathan R, et al.
PMID 18558872
Ravi V, et al.
PMID 12467975
Ravi V, et al.
PMID 15891128

Updated

Nov 13, 2013

Data Source: 
tts