Technology Bundle ID: TAB-2664

T24 Antigen for Diagnosing or Treating Taenia solium Cysticercosis

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Licensing Contact:
Primary Inventors: 
Kathy Hancock (CDC)
Co-Inventors: 
Fatima Williams (CDC), Melinda Yushak (CDC), Sowmya Pattabhi (CDC), Victor Tsang (CDC)
Development Status: 
  • Early-stage
  • In vitro data available
Institute or Center: 
CDC

In order to develop a simple detection assay for field use, CDC researchers cloned and sequenced the Taenia solium T24 diagnostic protein. The T24 sequences can be used to detect and diagnose T. solium infection or can be formulated into a pharmaceutical composition. T. solium is a species of tapeworm. Intestinal infection with T. solium is referred to as taeniasis. Many taeniasis infections are asymptomatic but may be characterized by insomnia, anorexia, abdominal pain and weight loss. Cysticercosis infection, which can be fatal, may develop if T. solium larvae migrate out of the intestine and form cysticerci in various body tissues. This technology may be used to develop a diagnostic, vaccine, or therapeutic for infection related to T. solium.

Applications:
  • Vaccine or therapeutic for taeniasis or cysticercosis resulting from T. solium infection
  • Diagnosis of T. solium infection
  • Zoonotic disease research and surveillance
  • Public health monitoring programs
  • Livestock health and food-source monitoring
Advantages:
  • Rapid, accurate, sensitive, and safe compared to current radiologic and biopsy diagnostic methods
  • Easy-to-use diagnostic kit that doesn't require abnormal temperatures or specialized equipment
  • Can be developed for serologic and/or nucleic acid diagnostics
  • Cost-effective; useful for developing countries

Patents

PCT Application PCT/US2004/015041
Filed on 2004-05-13
US Application 60/471,950
Filed on 2003-05-19
US Pat 7,547,762

Issued 2009-06-16
US Pat 7,972,606

Issued 2011-07-05

Updated

Oct 23, 2013

Data Source: 
tts