Technology Bundle ID: TAB-2658

Real-Time PCR Assay for Specific Detection of Haemophilus influenzae Serotypes A and B

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Licensing Contact:
Primary Inventors: 
Jennifer Thomas (CDC)
Co-Inventors: 
Cynthia Hatcher (CDC), Leonard Mayer (CDC), Mary Theodore (CDC), Raydel Anderson (CDC), Xin Wang (CDC)
Therapeutic Area: 
Infectious Disease
Application: 
Diagnostics
Development Status: 
  • Early-stage
  • Pre-clinical
  • In vitro data available
Institute or Center: 
CDC

Haemophilus influenzae is responsible for life-threatening respiratory infections including meningitis. This assay allows for the qualitative detection of the bacterial meningitis pathogen H. influenzae serotype A (Hia) and serotype B (Hib) in fluid samples, without detecting any of the other serotypes of H. influenzae. This invention is capable of detecting even the very small numbers of Hia or Hib within clinical specimens.

Applications:
  • Meningitis nucleic acid-based diagnostics for testing clinical samples
  • Useful for public health monitoring programs
  • Surveillance of circulating H. influenzae serotypes
Advantages:
  • Easily adapted to a real-time PCR assay (monoplex or multiplex) kit
  • Rapid, accurate and specific, especially when compared to sero-diagnostic approaches
  • No further testing need, presently ready for commercialization

Patents

PCT Application PCT/US2012/022753
Filed on 2012-01-26
US Application 61/436,535
Filed on 2011-01-26
US Pat 10,669,591

Issued 2020-06-02
US Pat 10,683,558

Issued 2020-06-16
US Pat 9,593,385

Issued 2017-03-14

Updated

Oct 18, 2013

Data Source: 
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