Technology Bundle ID: TAB-2622

Composition and Methods for Rapid Detection of HIV by Loop-mediated Isothermal Amplification

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Licensing Contact:
Donna Rudolph (CDC), Kelly Curtis (CDC)
Therapeutic Area: 
Infectious Disease
Development Status: 
  • Pre-clinical
  • In vitro data available
Institute or Center: 

This invention relates to methods and compositions for rapid detection of HIV nucleic acids in a biological sample. Specifically, it involves the use of the loop-mediated isothermal amplification (LAMP) for rapid detection of HIV-1 and/or HIV-2. The use of rapid HIV tests is highly attractive for screening of patient samples, especially in developing countries where resources are limited, because they are quick, easy to perform, and do not require any special equipment. Rapid tests for the identification of HIV antibody, however, will remain negative during the 4 to 5 week window post-infection and pre-seroconversion, necessitating the need for a diagnosis based on HIV nucleic acid.

  • Diagnostic test for HIV-1 and/or HIV-2 infection
  • Kits for detection of HIV nucleic acids
  • High sensitivity and specificity.
  • No need for thermal cyclers or gel electrophoresis
  • Assay can be used in limited-resource settings.
  • A rapid, portable and cost-effective alternative to PCR and enzyme immune assays.


PCT Application PCT/US09/035130
Filed on 2009-02-25
US Application 61/031,128
Filed on 2008-02-25
US Pat 8,900,807

Issued 2014-12-02


Curtis KA, et al.
PMID 18524393
Curtis KA, et al.
PMID 19382260
Curtis KA, et al.
PMID 22384022


Aug 23, 2013

Data Source: