Technology Bundle ID
TAB-2622

Composition and Methods for Rapid Detection of HIV by Loop-mediated Isothermal Amplification

Applications
Diagnostics
Linked ID
E-173-2013-0
Co-Inventors
Donna Rudolph (CDC)
Kelly Curtis (CDC)
Development Status
  • Pre-clinical
  • In vitro data available
Therapeutic Areas
Infectious Disease
ICs
CDC
This invention relates to methods and compositions for rapid detection of HIV nucleic acids in a biological sample. Specifically, it involves the use of the loop-mediated isothermal amplification (LAMP) for rapid detection of HIV-1 and/or HIV-2. The use of rapid HIV tests is highly attractive for screening of patient samples, especially in developing countries where resources are limited, because they are quick, easy to perform, and do not require any special equipment. Rapid tests for the identification of HIV antibody, however, will remain negative during the 4 to 5 week window post-infection and pre-seroconversion, necessitating the need for a diagnosis based on HIV nucleic acid.
Commercial Applications
  • Diagnostic test for HIV-1 and/or HIV-2 infection
  • Kits for detection of HIV nucleic acids
Competitive Advantages
  • High sensitivity and specificity.
  • No need for thermal cyclers or gel electrophoresis
  • Assay can be used in limited-resource settings.
  • A rapid, portable and cost-effective alternative to PCR and enzyme immune assays.

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