Technology Bundle ID: TAB-2613

Real-Time PCR for Detecting Legionella Species and Discriminating Legionella pneumophila

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Primary Inventors: 
Patrick Yang (CDC)
Brian Holloway (CDC), Karen McCaustland (CDC), Robert Benson (CDC)
Therapeutic Area: 
Infectious Disease
Development Status: 
  • Early-stage
  • In vitro data available
Institute or Center: 

Legionella pneumophila is the causative species in most cases of Legionnaires' disease (LD). CDC scientists have developed a real-time PCR assay capable of detecting all Legionella species and discriminating L. pneumophila from other Legionella species. LD is typically difficult to diagnose from a clinical standpoint as it confers no unique clinical features or symptoms. This assay provides a rapid and accurate alternative to laborious PCR assays, prone to aberrant results. It provides a sensitive alternative for diagnosis of Legionnaires' disease and detection of L. pneumophila.

  • Diagnostic for Legionnaires’ disease
  • Detection of all Legionella species and specific discrimination of L. pneumophila
  • Faster than immunoassays
  • Less laborious than current LD diagnostics
  • Rapid, sensitive, and specific
  • Curtails misdiagnoses associated with serological evaluations
  • Easily adaptable to kit form


PCT Application PCT/US2009/068461
Filed on 2009-12-17
US Application 13/140,922
Filed on 2011-09-12
US Application 61/138,727
Filed on 2008-12-18


Yang G, et al.
PMID 19438641


Aug 13, 2013

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