Technology Bundle ID: TAB-2464

Salen-Manganese Compounds for Therapy of Viral Infections

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Licensing Contact:
Primary Inventors: 
John Kash (NIAID)
Co-Inventors: 
Jeffery Taubenberger (NIAID), Rodney Levine (NHLBI), Susan Doctrow (Boston University)
Therapeutic Area: 
Infectious Disease
Application: 
Therapeutics
Development Status: 
  • Early-stage
  • Pre-clinical
  • In vivo data available (animal)
Institute or Center: 
NHLBI, NIAID

Salen-manganese compounds are synthetic, stable, low toxicity, low cost agents that may provide protection from immune reaction-related oxidative cell damage associated with many illnesses. In particular, oxidative cell damage has been associated with many viral infections including influenza. This invention demonstrates that treating mice with salen-manganese compounds, after lethal pandemic influenza virus infection, significantly enhances survival. Salen-manganese treatment also reduces lung pathology and also improved cellular recovery and repair. Because oxidative damage is observed in many viral infections, administration of salen-manganese compounds may have therapeutic relevance to a wide range of viral infections, in addition influenza. Existing viral therapeutics merely target the infectious viral agent and not the damage caused by the immune system reaction related to infection. Because, salen-manganese treatments target the untapped therapeutic space of infection-induced, immune system-related pathology and have favorable safety and cost profiles, such therapies are ideal candidates for development.

Applications:
  • Viral therapeutics.
Advantages:
  • Synthetic, stable, low toxicity, low cost, untapped therapeutic target space.

Patents

PCT Application PCT/US2012/064383
Filed on 2012-11-09
US Application 61/558,137
Filed on 2011-11-10
US Pat 10,683,316

Issued 2020-06-16

Publications

Doctrow SR, et al. Salen Manganese Complexes: Multifunctional Catalytic Antioxidants Protective in Models for Neurodegenerative Diseases of Aging. In: Medicinal Inorganic Chemistry, ACS Symposium Series, Vol. 903, Chapter 18, pp 319-347; August 25, 2005.
DOI: 10.1021/bk-2005-0903.ch018
Schwarz KB.
PMID 8891667

Updated

Jul 20, 2012

Data Source: 
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