Technology Bundle ID: TAB-2320

Rapid Molecular Assays for Specific Detection and Quantitation of Loa Loa Microfilaremia

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Licensing Contact:
Primary Inventors: 
Thomas Nutman (NIAID)
Co-Inventors: 
Doran Fink (NIAID)
Therapeutic Area: 
Infectious Disease
Application: 
Diagnostics
Development Status: 
  • Early-stage
  • Pre-clinical
Institute or Center: 
NIAID

The risk of fatal reactions in some infected individuals administered drug treatments for Loa loa infection, and the lack of accurate, convenient, diagnostics for this infection have thwarted efforts to eradicate the disease. Time consuming, labor intensive and training intensive microscope-based analysis of blood samples is the standard available diagnostic for Loa loa infection. This new assay technology introduces an easy to use, species-specific, highly sensitive, diagnostic that is able to be performed with minimal training. Positive test results may be indicated by an easily visualized color change and this test may be run without the need for expensive equipment such as a thermocycler. Because this test is rapid, cost efficient, labor efficient, accurate, and simple to run and read, it may be readily incorporated into portable point-of-care formats. These attributes make it ideally suited for use in locations where Loa loa infection is endemic. These advantages may lead to this technology becoming the new standard for diagnosis of Loa loa infections and a valuable tool, in control programs, to identify risks for adverse treatment reactions.

Applications:
  • Diagnostics testing
  • Infectious disease monitoring
Advantages:
  • Greater speed cost and labor efficiencies, accurate, and simple to run and read and ability to be incorporated into portable point-of-care format, ideally suited for Loa loa endemic regions.

Patents

PCT Application PCT/US2011/58565
Filed on 2011-10-31
US Application 61/410,232
Filed on 2010-11-04

Available for research use only.

Publications

Fink DL, et al.
PMID 21912716
Klion AD, et al.
PMID 2038361

Updated

Sep 29, 2011

Data Source: 
tts