Role of Novel Hepatitis Delta Virus Variant in Sjogren’s Syndrome


Sjögren’s is a chronic autoimmune disease characterized by dry mouth and eyes, fatigue, and musculoskeletal pain resulting from the attack of the moisture-producing glands by the body’s own white blood cells. The subject invention is based on the discovery of an association between infection by a novel clade 1 variant of hepatitis delta virus (HDV) and primary Sjögren’s syndrome. The association was made after detection of the HDV nucleic acid in the salivary glands of patients diagnosed with Sjögren’s syndrome and in vivo studies in mice that developed Sjögren’s syndrome-like pathogenesis after expression of HDV antigen. The discovery of this link opens the possibilities for developing diagnostics against HDV to determine who are at risk for developing Sjögren’s syndrome. The novel HDV variant can also serve as a potential therapeutic target for preventing or treating Sjögren’s.

Potential Commercial Applications: Competitive Advantages:
  • Diagnostic for novel HDV clade 1 variant as a risk factor for developing Sjögren’s
  • Therapeutics against this newly discovered HDV clade 1 variant for prevention and/or treatment of Sjögren’s syndrome
 
  • Novel diagnostic for a potentially significant risk factor in developing Sjögren’s syndrome
  • Newly discovered potential targets for treatment of Sjögren’s


Development Stage:
  • Early-stage
  • In vitro data available
  • In vivo data available (animal)


Inventors:

John Chiorini (NIDCR)  ➽ more inventions...

Melodie Weller (NIDCR)  ➽ more inventions...


Intellectual Property:
US Application No. 61/888,706

Collaboration Opportunity:

The National Institute of Dental and Craniofacial Research is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize Role of Novel Hepatitis Delta Virus Variant. For collaboration opportunities, please contact David W. Bradley, Ph.D. at bradleyda@nidcr.nih.gov.


Licensing Contact:
Sally Hu, Ph.D., M.B.A.
Email: hus@mail.nih.gov
Phone: 301-594-2616

OTT Reference No: E-736-2013/0
Updated: Apr 14, 2014