Nucleic Acid-based Compositions and Methods for the Species-Specific Detection of Pathogenic Candida Fungi


This invention pertains to the development of oligonucleotides for the rapid nucleic acid-based identification of the Candida fungi species C. haemulonii, C. kefyr, C. lambica, C. lusitaniae, C. norvegensis, C. norvegica, C. rugosa, C. utilis, C. viswanathii, C. zeylanoides, C. dubliniensis, and C. pelliculosa within biological samples. This identification is accomplished by the targeting the internally transcribed spacer-2 (ITS2) region that are specific for each species. The assay is sensitive, specific and rapid. Implementation of the technology will facilitate earlier specific diagnoses, and lead to better antifungal therapy implementation for infected patients.

Potential Commercial Applications: Competitive Advantages:
  • Directing antifungal drug therapy for improved patient outcomes
  • Detection, discrimination of Candida species from biological samples
  • Addressing secondary infections of immunosuppressed individuals
 
  • Easily adapted for use in kits
  • High-throughput capable
  • Rapid and cost-effective


Development Stage:
In vitro data available

Related Invention(s):
E-232-2013/0
E-293-2013/0
E-332-2013/0
E-335-2013/0
E-339-2013/0


Inventors:

Christine Morrison (CDC)  ➽ more inventions...

Errol Reiss (CDC)  ➽ more inventions...

Timonthy Lott (CDC)  ➽ more inventions...

Cheryl Elie (CDC)  ➽ more inventions...


Intellectual Property:
U.S. Pat: 6,242,178 issued 2001-06-05
PCT Application No. PCT/US1998/015840

Publications:
Shin JH, et al. PMID 9854084

Licensing Contact:
Tara Kirby, Ph.D.
Email: tara.kirby@nih.gov
Phone: 240-669-5128

OTT Reference No: E-340-2013/0
Updated: Dec 23, 2013