Nucleic Acid Assays for the Detection and Discrimination of Aspergillus Fungi Species within Biological Samples


This invention relates to assays for the detection and species-specific identification of Aspergillus fungi. Accurate clinical diagnosis of Aspergillus species has become increasingly important as certain species, such as A. terreus and A. fumigatus, are resistant to specific commonly employed antifungal compounds. Most contemporary fungal diagnostic methods are time-consuming and inaccurate. This invention directly addresses those inadequacies by providing a method to rapidly and accurately differentiate all medically important species of Aspergillus based on differences in the DNA sequences of the internal transcribed spacer 1 region of ribosomal DNA.

Potential Commercial Applications: Competitive Advantages:
  • Directing antifungal drug therapy for improved patient outcomes
  • Detection, discrimination of Aspergillus species from biological samples
  • Addressing secondary infections of immunosuppressed individuals or asthmatics
 
  • Easily adapted for use in kits
  • Assay may be used in real-time PCR, in enzyme immunoassays and/or in microarrays
  • High-throughput capable


Development Stage:
In vitro data available

Related Invention(s):
E-232-2013/0
E-293-2013/0
E-332-2013/0


Inventors:

Christine Morrison (CDC)  ➽ more inventions...

Hans Hinrikson (CDC)  ➽ more inventions...


Intellectual Property:
U.S. Pat: 7,384,741 issued 2008-06-10
U.S. Pat: 7,871,779 issued 2011-01-18
US Application No. 10/514,861
US Application No. 12/115,493

Publications:
Hinrikson HP, et al. PMID 15872227
CDC Fact Sheet: Aspergillosis http://www.cdc.gov/fungal/aspergillosis/

Licensing Contact:
Tara Kirby, Ph.D.
Email: tara.kirby@nih.gov
Phone: 240-669-5128

OTT Reference No: E-335-2013/0
Updated: Dec 23, 2013